Embryonal carcinoma of the ovary. A clinicopathologic entity distinct from endodermal sinus tumor resembling embryonal carcinoma of the adult testis

Robert J Kurman, H. J. Norris

Research output: Contribution to journalArticle

Abstract

The clinical and pathologic features of 15 examples of a hitherto undescribed germ cell tumor of the ovary are delineated. This tumor resembles the embryonal carcinoma of the adult testis and may be distinguished from the endodermal sinus tumor on the basis of its histologic and immunohistochemical characteristics. An indirect immunoperoxidase method for the localization of human chorionic gonadotropin (HCG) and alpha fetoprotein (AFP) was carried out on formalin fixed paraffin embedded tissue from 10 neoplasms; HCG was present in all 10 neoplasms, and AFP was found in 7. HCG was identified only in cells resembling the syncytiotrophoblast, whereas AFP was present only in mononuclear embryonal cells, indicating that the 2 protein antigens were localized in different cell types. Abnormal hormonal manifestations, consisting of precocious puberty, irregular bleeding, amenorrhea, or hirsutism, were present in 9 (60%) of the patients. The acturial survival for the entire group was 39%; for those with stage I tumors, 50%. The authors propose the term 'embryonal carcinoma' for this neoplasm in order to distinguish it from the more common endodermal sinus tumor of the ovary and to emphasize the histologic similarity to embryonal carcinoma of the adult testis.

Original languageEnglish (US)
Pages (from-to)2420-2433
Number of pages14
JournalCancer
Volume38
Issue number6
StatePublished - 1976
Externally publishedYes

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Embryonal Carcinoma
Endodermal Sinus Tumor
Testis
Ovary
alpha-Fetoproteins
Chorionic Gonadotropin
Germ Cell and Embryonal Neoplasms
Neoplasms
Precocious Puberty
Hirsutism
Amenorrhea
Trophoblasts
Paraffin
Formaldehyde
Hemorrhage
Antigens
Survival
Proteins

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

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title = "Embryonal carcinoma of the ovary. A clinicopathologic entity distinct from endodermal sinus tumor resembling embryonal carcinoma of the adult testis",
abstract = "The clinical and pathologic features of 15 examples of a hitherto undescribed germ cell tumor of the ovary are delineated. This tumor resembles the embryonal carcinoma of the adult testis and may be distinguished from the endodermal sinus tumor on the basis of its histologic and immunohistochemical characteristics. An indirect immunoperoxidase method for the localization of human chorionic gonadotropin (HCG) and alpha fetoprotein (AFP) was carried out on formalin fixed paraffin embedded tissue from 10 neoplasms; HCG was present in all 10 neoplasms, and AFP was found in 7. HCG was identified only in cells resembling the syncytiotrophoblast, whereas AFP was present only in mononuclear embryonal cells, indicating that the 2 protein antigens were localized in different cell types. Abnormal hormonal manifestations, consisting of precocious puberty, irregular bleeding, amenorrhea, or hirsutism, were present in 9 (60{\%}) of the patients. The acturial survival for the entire group was 39{\%}; for those with stage I tumors, 50{\%}. The authors propose the term 'embryonal carcinoma' for this neoplasm in order to distinguish it from the more common endodermal sinus tumor of the ovary and to emphasize the histologic similarity to embryonal carcinoma of the adult testis.",
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N2 - The clinical and pathologic features of 15 examples of a hitherto undescribed germ cell tumor of the ovary are delineated. This tumor resembles the embryonal carcinoma of the adult testis and may be distinguished from the endodermal sinus tumor on the basis of its histologic and immunohistochemical characteristics. An indirect immunoperoxidase method for the localization of human chorionic gonadotropin (HCG) and alpha fetoprotein (AFP) was carried out on formalin fixed paraffin embedded tissue from 10 neoplasms; HCG was present in all 10 neoplasms, and AFP was found in 7. HCG was identified only in cells resembling the syncytiotrophoblast, whereas AFP was present only in mononuclear embryonal cells, indicating that the 2 protein antigens were localized in different cell types. Abnormal hormonal manifestations, consisting of precocious puberty, irregular bleeding, amenorrhea, or hirsutism, were present in 9 (60%) of the patients. The acturial survival for the entire group was 39%; for those with stage I tumors, 50%. The authors propose the term 'embryonal carcinoma' for this neoplasm in order to distinguish it from the more common endodermal sinus tumor of the ovary and to emphasize the histologic similarity to embryonal carcinoma of the adult testis.

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