EMBRYOGENESIS IN MAMMALS

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The expression of cell surface antigens determined by genes of the major histocompatibility complex, H 2, of the mouse has been studied in embryos. Antigens of this complex may be present on gametes but are undetectable on embryos up to six days of development. H 2 expression may also be studied in two different types of cell lines: teratomas and the blastocyst derived MB lines. The former lines have been shown to be H 2 negative, both serologically and by grafting; they bear antigens which are present in embryos at stages lacking H 2, and one of these antigens may be physically associated with H 2 on tumour cell surfaces. The second set of lines, the MB lines, partially express H 2 antigens; only some structural features of their H 2 molecules are accessible to antibody. Two models are described for this partial expression which have more general application to expression of the properties of cell surfaces in development. One model suggests that specific associations of membrane molecules may alter their reactions with ligands in the medium or on other cells. A second model proposes that constraints on the diffusion of membrane proteins in the plane of the membrane can radically affect the interactions of these proteins with the external environment.

Original languageEnglish (US)
Title of host publicationCIBA FOUND.SYMP.
Pages177-197
Number of pages21
VolumeNo. 40
StatePublished - 1976

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H-2 Antigens
Embryonic Development
Mammals
Embryonic Structures
Antigens
Membranes
Surface Properties
Teratoma
Blastocyst
Surface Antigens
Major Histocompatibility Complex
Germ Cells
Membrane Proteins
Ligands
Cell Line
Antibodies
Genes
Neoplasms
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Edidin, M. A. (1976). EMBRYOGENESIS IN MAMMALS. In CIBA FOUND.SYMP. (Vol. No. 40, pp. 177-197)

EMBRYOGENESIS IN MAMMALS. / Edidin, Michael A.

CIBA FOUND.SYMP.. Vol. No. 40 1976. p. 177-197.

Research output: Chapter in Book/Report/Conference proceedingChapter

Edidin, MA 1976, EMBRYOGENESIS IN MAMMALS. in CIBA FOUND.SYMP.. vol. No. 40, pp. 177-197.
Edidin MA. EMBRYOGENESIS IN MAMMALS. In CIBA FOUND.SYMP.. Vol. No. 40. 1976. p. 177-197
Edidin, Michael A. / EMBRYOGENESIS IN MAMMALS. CIBA FOUND.SYMP.. Vol. No. 40 1976. pp. 177-197
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