Embedding high-dimensional Bayesian optimization via generative modeling: Parameter personalization of cardiac electrophysiological models

Jwala Dhamala, Pradeep Bajracharya, Hermenegild J. Arevalo, John L L. Sapp, B. Milan Horácek, Katherine C. Wu, Natalia A. Trayanova, Linwei Wang

Research output: Contribution to journalArticle


The estimation of patient-specific tissue properties in the form of model parameters is important for personalized physiological models. Because tissue properties are spatially varying across the underlying geometrical model, it presents a significant challenge of high-dimensional (HD) optimization at the presence of limited measurement data. A common solution to reduce the dimension of the parameter space is to explicitly partition the geometrical mesh. In this paper, we present a novel concept that uses a generative variational auto-encoder (VAE) to embed HD Bayesian optimization into a low-dimensional (LD) latent space that represents the generative code of HD parameters. We further utilize VAE-encoded knowledge about the generative code to guide the exploration of the search space. The presented method is applied to estimating tissue excitability in a cardiac electrophysiological model in a range of synthetic and real-data experiments, through which we demonstrate its improved accuracy and substantially reduced computational cost in comparison to existing methods that rely on geometry-based reduction of the HD parameter space.

Original languageEnglish (US)
Article number101670
JournalMedical image analysis
StatePublished - May 2020



  • High-dimensional Bayesian optimization
  • personalized modeling
  • variational autoencoder

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Computer Vision and Pattern Recognition
  • Health Informatics
  • Computer Graphics and Computer-Aided Design

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