Embedded Phase-Amplitude Coupling Based Closed-loop Platform for Parkinson's Disease

M. Alexandre, S. Luan, Z. Mari, William S Anderson, Yousef Salimpour, T. G. Constandinou, L. B. Grand

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Deep Brain Stimulation (DBS) is a widely used clinical therapeutic modality to treat Parkinsons disease refractory symptoms and complications of levodopa therapy. Currently available DBSsystems use continuous, open-loop stimulation strategies. It might be redundant and we could extend the battery life otherwise. Recently, robust electrophysiological signatures of Parkinsons disease have been characterized in motor cortex of patients undergoing DBS surgery. Reductions in the beta-gamma Phase-Amplitude coupling (PAC) correlated with symptom improvement, and the therapeutic effects of DBS itself. We aim to develop a miniature, implantable and adaptive system, which only stimulates the neural target, when triggered by the output of the appropriate PAC algorithm. As a first step, in this paper we compare published PAC algorithms by using human data intra-operatively recorded from Parkinsonian patients. We then introduce IIR masking for later achieving fast and low-power FPGA implementation of PAC mapping for intra-operative studies. Our closed-loop application is expected to consume significantly less power than current DBS systems, therefore we can increase the battery life, without compromising clinical benefits.

Original languageEnglish (US)
Title of host publication2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781538636039
DOIs
Publication statusPublished - Dec 20 2018
Event2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018 - Cleveland, United States
Duration: Oct 17 2018Oct 19 2018

Other

Other2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018
CountryUnited States
CityCleveland
Period10/17/1810/19/18

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ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Health Informatics
  • Instrumentation
  • Signal Processing
  • Biomedical Engineering

Cite this

Alexandre, M., Luan, S., Mari, Z., Anderson, W. S., Salimpour, Y., Constandinou, T. G., & Grand, L. B. (2018). Embedded Phase-Amplitude Coupling Based Closed-loop Platform for Parkinson's Disease. In 2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018 - Proceedings [8584699] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BIOCAS.2018.8584699