Abstract
The amygdala has attracted considerable research interest because of its potential involvement in various neuropsychiatric disorders. Recently, attempts have been made using magnetic resonance imaging (MRI) to evaluate the integrity of the axonal connections to and from the amygdala under pathological conditions. Although amygdalar pathways have been studied extensively in animal models, anatomical references for the human brain are limited to histology-based resources from a small number of slice locations, orientations and annotations. In the present study, we performed high-resolution (250 µm) MRI of postmortem human brains followed by serial histology sectioning. The histology data were used to identify amygdalar pathways, and the anatomical delineation of the assigned structures was extended into 3D using the MRI data. We were able to define the detailed anatomy of the stria terminalis and amygdalofugal pathway, as well as the anatomy of the nearby basal forebrain areas, including the substantia innominata. The present results will help us understand in detail the white matter structures associated with the amygdala, and will serve as an anatomical reference for the design of in vivo MRI studies and interpretation of their data.
| Language | English (US) |
|---|---|
| Article number | 16 |
| Journal | Frontiers in Neuroanatomy |
| Volume | 11 |
| DOIs | |
| State | Published - Mar 14 2017 |
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Keywords
- Amygdala
- Amygdalofugal pathway
- Diffusion tensor imaging
- Histology
- Microimaging
- MRI
- Stria terminalis
- White matter anatomy
ASJC Scopus subject areas
- Neuroscience (miscellaneous)
- Anatomy
- Cellular and Molecular Neuroscience
Cite this
Elucidation of white matter tracts of the human amygdala by detailed comparison between high-resolution postmortem magnetic resonance imaging and histology. / Mori, Susumu; Kageyama, Yusuke; Hou, Zhipeng; Aggarwal, Manisha; Patel, Jaymin; Brown, Timothy; Miller, Michael I.; Wu, Dan; Troncoso, Juan C.
In: Frontiers in Neuroanatomy, Vol. 11, 16, 14.03.2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Elucidation of white matter tracts of the human amygdala by detailed comparison between high-resolution postmortem magnetic resonance imaging and histology
AU - Mori,Susumu
AU - Kageyama,Yusuke
AU - Hou,Zhipeng
AU - Aggarwal,Manisha
AU - Patel,Jaymin
AU - Brown,Timothy
AU - Miller,Michael I.
AU - Wu,Dan
AU - Troncoso,Juan C.
PY - 2017/3/14
Y1 - 2017/3/14
N2 - The amygdala has attracted considerable research interest because of its potential involvement in various neuropsychiatric disorders. Recently, attempts have been made using magnetic resonance imaging (MRI) to evaluate the integrity of the axonal connections to and from the amygdala under pathological conditions. Although amygdalar pathways have been studied extensively in animal models, anatomical references for the human brain are limited to histology-based resources from a small number of slice locations, orientations and annotations. In the present study, we performed high-resolution (250 µm) MRI of postmortem human brains followed by serial histology sectioning. The histology data were used to identify amygdalar pathways, and the anatomical delineation of the assigned structures was extended into 3D using the MRI data. We were able to define the detailed anatomy of the stria terminalis and amygdalofugal pathway, as well as the anatomy of the nearby basal forebrain areas, including the substantia innominata. The present results will help us understand in detail the white matter structures associated with the amygdala, and will serve as an anatomical reference for the design of in vivo MRI studies and interpretation of their data.
AB - The amygdala has attracted considerable research interest because of its potential involvement in various neuropsychiatric disorders. Recently, attempts have been made using magnetic resonance imaging (MRI) to evaluate the integrity of the axonal connections to and from the amygdala under pathological conditions. Although amygdalar pathways have been studied extensively in animal models, anatomical references for the human brain are limited to histology-based resources from a small number of slice locations, orientations and annotations. In the present study, we performed high-resolution (250 µm) MRI of postmortem human brains followed by serial histology sectioning. The histology data were used to identify amygdalar pathways, and the anatomical delineation of the assigned structures was extended into 3D using the MRI data. We were able to define the detailed anatomy of the stria terminalis and amygdalofugal pathway, as well as the anatomy of the nearby basal forebrain areas, including the substantia innominata. The present results will help us understand in detail the white matter structures associated with the amygdala, and will serve as an anatomical reference for the design of in vivo MRI studies and interpretation of their data.
KW - Amygdala
KW - Amygdalofugal pathway
KW - Diffusion tensor imaging
KW - Histology
KW - Microimaging
KW - MRI
KW - Stria terminalis
KW - White matter anatomy
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UR - http://www.scopus.com/inward/citedby.url?scp=85015448991&partnerID=8YFLogxK
U2 - 10.3389/fnana.2017.00016
DO - 10.3389/fnana.2017.00016
M3 - Article
VL - 11
JO - Frontiers in Neuroanatomy
T2 - Frontiers in Neuroanatomy
JF - Frontiers in Neuroanatomy
SN - 1662-5129
M1 - 16
ER -