Elucidating the elite: mechanisms of control in HIV-1 infection

Karen A. O'Connell, Justin Bailey, Joel N Blankson

Research output: Contribution to journalArticle

Abstract

In patients with progressive disease, untreated HIV-1 infection is characterized by high viral loads and decreasing CD4+T cell counts which lead to opportunistic infection and other AIDS-defining illness. A rare subset of patients termed 'elite controllers' (ECs) maintain control over viremia and often retain normal CD4+T cell levels without treatment with antiretroviral drugs. For the most part these patients are infected with replication-competent, fit virus. Factors such as strong, polyfunctional cytotoxic T lymphocyte (CTL) responses and retention of T cell proliferative ability appear to be important in control of HIV-1. Defining what enables ECs to control viral replication will aid in the development of effective vaccine and treatment regimens. This review will discuss differences between ECs and progressors while emphasizing recent findings on the immunological response of ECs to HIV-1.

Original languageEnglish (US)
Pages (from-to)631-637
Number of pages7
JournalTrends in Pharmacological Sciences
Volume30
Issue number12
DOIs
StatePublished - Dec 2009

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T-cells
HIV Infections
HIV-1
T-Lymphocytes
Controllers
Viremia
Opportunistic Infections
Cytotoxic T-Lymphocytes
CD4 Lymphocyte Count
Viral Load
Acquired Immunodeficiency Syndrome
Vaccines
Viruses
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Elucidating the elite : mechanisms of control in HIV-1 infection. / O'Connell, Karen A.; Bailey, Justin; Blankson, Joel N.

In: Trends in Pharmacological Sciences, Vol. 30, No. 12, 12.2009, p. 631-637.

Research output: Contribution to journalArticle

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