Elite suppressors have low frequencies of intact HIV-1 proviral DNA

Abena K.R. Kwaa, Caroline C. Garliss, Kristen D. Ritter, Gregory M. Laird, Joel N. Blankson

Research output: Contribution to journalArticlepeer-review

Abstract

Elite controllers or suppressors control viral replication without antiretroviral therapy. We used the intact proviral DNA assay to approximate the size of the inducible latent reservoir in elite suppressors and found that, while the median frequency of both total and intact proviral DNA was markedly lower than the frequencies seen in chronic progressors on antiretroviral therapy there was no significant difference in the ratio of intact to total proviral DNA between elite suppressors and chronic progressors.

Original languageEnglish (US)
Pages (from-to)641-643
Number of pages3
JournalAIDS
Volume34
Issue number4
DOIs
StatePublished - Mar 15 2020

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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