Elite suppressors have low frequencies of intact HIV-1 proviral DNA

Abena K.R. Kwaa; Caroline C. Garliss; Kristen D. Ritter; Gregory M. Laird; Joel N. Blankson

doi:10.1097/QAD.0000000000002474

Elite suppressors have low frequencies of intact HIV-1 proviral DNA

Abena K.R. Kwaa, Caroline C. Garliss, Kristen D. Ritter, Gregory M. Laird, Joel N. Blankson

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Elite controllers or suppressors control viral replication without antiretroviral therapy. We used the intact proviral DNA assay to approximate the size of the inducible latent reservoir in elite suppressors and found that, while the median frequency of both total and intact proviral DNA was markedly lower than the frequencies seen in chronic progressors on antiretroviral therapy there was no significant difference in the ratio of intact to total proviral DNA between elite suppressors and chronic progressors.

Original language	English (US)
Pages (from-to)	641-643
Number of pages	3
Journal	AIDS
Volume	34
Issue number	4
DOIs	https://doi.org/10.1097/QAD.0000000000002474
State	Published - Mar 15 2020

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1097/QAD.0000000000002474

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title = "Elite suppressors have low frequencies of intact HIV-1 proviral DNA",

abstract = "Elite controllers or suppressors control viral replication without antiretroviral therapy. We used the intact proviral DNA assay to approximate the size of the inducible latent reservoir in elite suppressors and found that, while the median frequency of both total and intact proviral DNA was markedly lower than the frequencies seen in chronic progressors on antiretroviral therapy there was no significant difference in the ratio of intact to total proviral DNA between elite suppressors and chronic progressors.",

author = "Kwaa, {Abena K.R.} and Garliss, {Caroline C.} and Ritter, {Kristen D.} and Laird, {Gregory M.} and Blankson, {Joel N.}",

note = "Funding Information: Supported by the Johns Hopkins University Center for AIDS Research (P30AI094189) and the National Institute of Allergies and Infectious Diseases (R01AI120024, J.N.B.). Publisher Copyright: {\textcopyright} 2019-2020 Wolters Kluwer Health, Inc. All rights reserved.",

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AU - Kwaa, Abena K.R.

AU - Garliss, Caroline C.

AU - Ritter, Kristen D.

AU - Laird, Gregory M.

AU - Blankson, Joel N.

N1 - Funding Information: Supported by the Johns Hopkins University Center for AIDS Research (P30AI094189) and the National Institute of Allergies and Infectious Diseases (R01AI120024, J.N.B.). Publisher Copyright: © 2019-2020 Wolters Kluwer Health, Inc. All rights reserved.

PY - 2020/3/15

Y1 - 2020/3/15

N2 - Elite controllers or suppressors control viral replication without antiretroviral therapy. We used the intact proviral DNA assay to approximate the size of the inducible latent reservoir in elite suppressors and found that, while the median frequency of both total and intact proviral DNA was markedly lower than the frequencies seen in chronic progressors on antiretroviral therapy there was no significant difference in the ratio of intact to total proviral DNA between elite suppressors and chronic progressors.

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Elite suppressors have low frequencies of intact HIV-1 proviral DNA

Abstract

ASJC Scopus subject areas

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