Elevation of mouse kidney thiol content following administration of glutathione

Edward A. Bump, Ramsey Al-Sarraf, Susan M. Pierce, C. Norman Coleman

Research output: Contribution to journalArticlepeer-review

Abstract

We have found that kidney glutathione and cysteine content in OH mice can be increased by intraperitoneal administration of either glutathione (GSH) or glutathione disulfide (GSSG). Kidney thiol content is maximal 20-60 min after administration of 1000 mg/kg glutathione and returns to normal values by 2 h. The same time-course of thiol perturbation was observed when acivicin, an inhibitor of γ-glutamyl transpeptidase, was administered 15 min prior to GSSG administration. The increase in kidney thiols after GSSG administration appears to saturate, with little additional increase as the administered dose is increased above 750 mg/kg. There was no significant change in liver GSH or cysteine after GSSG administration. We suggest that glutathione administration may provide a strategy for selective radioprotection or chemoprotection of specialized cells which can effectively utilize systemic GSH precursors.

Original languageEnglish (US)
Pages (from-to)21-25
Number of pages5
JournalRadiotherapy and Oncology
Volume23
Issue number1
DOIs
StatePublished - Jan 1992

Keywords

  • Cysteine
  • Glutathione
  • Kidney

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

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