Elevated tissue sodium concentration in malignant breast lesions detected with non-invasive 23Na MRI

Ronald Ouwerkerk, Michael Jacobs, Katarzyna Macura, Antonio C Wolff, Vered Stearns, Sarah D. Mezban, Nagi Fouad Khouri, David A. Bluemke, Paul A Bottomley

Research output: Contribution to journalArticle

Abstract

Background: The hypothesis that physiological and biochemical changes associated with proliferating malignant tumors may cause an increase in total tissue sodium concentration (TSC) was tested with non-invasive, quantitative sodium (23Na) magnetic resonance imaging (MRI) in patients with benign and malignant breast tumors. Methods: 23Na and 1H MRI of the breast was performed on 22 women with suspicious breast lesions (≥1 cm) at 1.5 Tesla. A commercial proton (1H) phased array breast coil and custom solenoidal 23Na coil were used to acquire 1H and 23Na images during the same MRI examination. Quantitative 3-dimensional 23Na projection imaging was implemented with negligible signal loss from MRI relaxation, or from radio-frequency field inhomogeneity, in less than 15 min. Co-registered 1H and 23Na images permitted quantification of TSC in normal and suspicious tissues on the basis of 1H MRI contrast enhancement and anatomy, with histology confirmed by biopsy. Results: Sodium concentrations were consistently elevated in (N = 19) histologically proven malignant breast lesions by an average of 63% compared to glandular tissue. The increase in sodium concentration in malignant tissue was highly significant compared to unaffected glandular tissue (P <0.0001, paired t-test), adipose tissue, and TSC in three patients with benign lesions. Conclusion: Elevated TSC in breast lesions measured by non-invasive 23Na MRI appears to be a cellular-level indicator associated with malignancy. This method may have potential to improve the specificity of breast MRI with only a modest increase in scan time per patient.

Original languageEnglish (US)
Pages (from-to)151-160
Number of pages10
JournalBreast Cancer Research and Treatment
Volume106
Issue number2
DOIs
StatePublished - Dec 2007

Fingerprint

Breast
Sodium
Magnetic Resonance Imaging
Radio
Protons
Adipose Tissue
Neoplasms
Anatomy
Histology
Breast Neoplasms
Biopsy

Keywords

  • Na magnetic resonance
  • Breast cancer
  • Magnetic resonance imaging
  • Quantification
  • Sodium

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

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title = "Elevated tissue sodium concentration in malignant breast lesions detected with non-invasive 23Na MRI",
abstract = "Background: The hypothesis that physiological and biochemical changes associated with proliferating malignant tumors may cause an increase in total tissue sodium concentration (TSC) was tested with non-invasive, quantitative sodium (23Na) magnetic resonance imaging (MRI) in patients with benign and malignant breast tumors. Methods: 23Na and 1H MRI of the breast was performed on 22 women with suspicious breast lesions (≥1 cm) at 1.5 Tesla. A commercial proton (1H) phased array breast coil and custom solenoidal 23Na coil were used to acquire 1H and 23Na images during the same MRI examination. Quantitative 3-dimensional 23Na projection imaging was implemented with negligible signal loss from MRI relaxation, or from radio-frequency field inhomogeneity, in less than 15 min. Co-registered 1H and 23Na images permitted quantification of TSC in normal and suspicious tissues on the basis of 1H MRI contrast enhancement and anatomy, with histology confirmed by biopsy. Results: Sodium concentrations were consistently elevated in (N = 19) histologically proven malignant breast lesions by an average of 63{\%} compared to glandular tissue. The increase in sodium concentration in malignant tissue was highly significant compared to unaffected glandular tissue (P <0.0001, paired t-test), adipose tissue, and TSC in three patients with benign lesions. Conclusion: Elevated TSC in breast lesions measured by non-invasive 23Na MRI appears to be a cellular-level indicator associated with malignancy. This method may have potential to improve the specificity of breast MRI with only a modest increase in scan time per patient.",
keywords = "Na magnetic resonance, Breast cancer, Magnetic resonance imaging, Quantification, Sodium",
author = "Ronald Ouwerkerk and Michael Jacobs and Katarzyna Macura and Wolff, {Antonio C} and Vered Stearns and Mezban, {Sarah D.} and Khouri, {Nagi Fouad} and Bluemke, {David A.} and Bottomley, {Paul A}",
year = "2007",
month = "12",
doi = "10.1007/s10549-006-9485-4",
language = "English (US)",
volume = "106",
pages = "151--160",
journal = "Breast Cancer Research and Treatment",
issn = "0167-6806",
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}

TY - JOUR

T1 - Elevated tissue sodium concentration in malignant breast lesions detected with non-invasive 23Na MRI

AU - Ouwerkerk, Ronald

AU - Jacobs, Michael

AU - Macura, Katarzyna

AU - Wolff, Antonio C

AU - Stearns, Vered

AU - Mezban, Sarah D.

AU - Khouri, Nagi Fouad

AU - Bluemke, David A.

AU - Bottomley, Paul A

PY - 2007/12

Y1 - 2007/12

N2 - Background: The hypothesis that physiological and biochemical changes associated with proliferating malignant tumors may cause an increase in total tissue sodium concentration (TSC) was tested with non-invasive, quantitative sodium (23Na) magnetic resonance imaging (MRI) in patients with benign and malignant breast tumors. Methods: 23Na and 1H MRI of the breast was performed on 22 women with suspicious breast lesions (≥1 cm) at 1.5 Tesla. A commercial proton (1H) phased array breast coil and custom solenoidal 23Na coil were used to acquire 1H and 23Na images during the same MRI examination. Quantitative 3-dimensional 23Na projection imaging was implemented with negligible signal loss from MRI relaxation, or from radio-frequency field inhomogeneity, in less than 15 min. Co-registered 1H and 23Na images permitted quantification of TSC in normal and suspicious tissues on the basis of 1H MRI contrast enhancement and anatomy, with histology confirmed by biopsy. Results: Sodium concentrations were consistently elevated in (N = 19) histologically proven malignant breast lesions by an average of 63% compared to glandular tissue. The increase in sodium concentration in malignant tissue was highly significant compared to unaffected glandular tissue (P <0.0001, paired t-test), adipose tissue, and TSC in three patients with benign lesions. Conclusion: Elevated TSC in breast lesions measured by non-invasive 23Na MRI appears to be a cellular-level indicator associated with malignancy. This method may have potential to improve the specificity of breast MRI with only a modest increase in scan time per patient.

AB - Background: The hypothesis that physiological and biochemical changes associated with proliferating malignant tumors may cause an increase in total tissue sodium concentration (TSC) was tested with non-invasive, quantitative sodium (23Na) magnetic resonance imaging (MRI) in patients with benign and malignant breast tumors. Methods: 23Na and 1H MRI of the breast was performed on 22 women with suspicious breast lesions (≥1 cm) at 1.5 Tesla. A commercial proton (1H) phased array breast coil and custom solenoidal 23Na coil were used to acquire 1H and 23Na images during the same MRI examination. Quantitative 3-dimensional 23Na projection imaging was implemented with negligible signal loss from MRI relaxation, or from radio-frequency field inhomogeneity, in less than 15 min. Co-registered 1H and 23Na images permitted quantification of TSC in normal and suspicious tissues on the basis of 1H MRI contrast enhancement and anatomy, with histology confirmed by biopsy. Results: Sodium concentrations were consistently elevated in (N = 19) histologically proven malignant breast lesions by an average of 63% compared to glandular tissue. The increase in sodium concentration in malignant tissue was highly significant compared to unaffected glandular tissue (P <0.0001, paired t-test), adipose tissue, and TSC in three patients with benign lesions. Conclusion: Elevated TSC in breast lesions measured by non-invasive 23Na MRI appears to be a cellular-level indicator associated with malignancy. This method may have potential to improve the specificity of breast MRI with only a modest increase in scan time per patient.

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KW - Sodium

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