Elevated systemic microbial translocation in pregnant HIV-infected women compared to HIV-uninfected women, and its inverse correlations with plasma progesterone levels

Zejun Zhou, Anna Powell, Vishwanathan Ramakrishnan, Allison Eckard, Carol Wagner, Wei Jiang

Research output: Contribution to journalArticle

Abstract

In HIV infection, increased adverse perinatal outcomes reported among HIV-associated pregnancies are not fully understood. Currently, microbial product translocation (MT) from a permeable mucosa is demonstrated as a driver of inflammation, and may contribute to preterm delivery in HIV. Here, our results showed that plasma LPS levels (a representative marker of MT) were increased in HIV-infected women in the first and second trimester. Progesterone levels were significantly decreased in HIV-infected subjects in the first trimester and second trimester. There were significant inverse correlations between plasma LPS and progesterone in the first and second trimester. These results suggested heightened systemic MT and decreased plasma progesterone levels in HIV-infected pregnant women may play a role in increased incidence of preterm delivery.

Original languageEnglish (US)
Pages (from-to)16-18
Number of pages3
JournalJournal of Reproductive Immunology
Volume127
DOIs
StatePublished - Jun 1 2018
Externally publishedYes

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Keywords

  • HIV
  • Microbial translocation
  • Pregnancy
  • Progesterone

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology

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