TY - JOUR
T1 - Elevated serum advanced glycation end products and poor grip strength in older community-dwelling women
AU - Dalal, Mansi
AU - Ferrucci, Luigi
AU - Sun, Kai
AU - Beck, Justine
AU - Fried, Linda P.
AU - Semba, Richard D.
N1 - Funding Information:
This work was supported by National Institute on Aging grant R01 AG027012, AG11703-01A1, National Institutes of Health - National Center for Research Resources, Outpatient Department General Clinical Research Center grant RR00722, NIA Contract N01-AG12112, and the Intramural Research Program, National Institute on Aging, National Institutes of Health.
PY - 2009/1
Y1 - 2009/1
N2 - Background. Advanced glycation end products (AGEs) have been implicated in the pathogenesis of diabetes, heart disease, and kidney failure and may potentially affect skeletal muscle. Whether AGEs are associated with poor muscle strength is unknown. Methods. Serum carboxymethyl-lysine (CML), a dominant AGE, circulating soluble form of receptor for advanced glycation end products (sRAGE), and endogenous secretory receptor for advanced glycation end product (esRAGE) and grip strength were measured in 559 moderately to severely disabled women, age 65 and older, in the Women's Health and Aging Study I in Baltimore, Md. Results. Mean (standard deviation) grip strength among women in the highest quartile of serum CML compared with women in the lower three quartiles was 18.6 and 20.0 kg, respectively ( p =.002), adjusting for age, race, body mass index, cognitive dysfunction, depression, and diabetes. Serum sRAGE and esRAGE were not significantly associated with grip strength. Conclusions. Women with high serum AGEs have greater muscle weakness. Further studies are needed to determine whether AGEs, a potentially modifiable risk factor, are associated with physical performance and disability in older adults.
AB - Background. Advanced glycation end products (AGEs) have been implicated in the pathogenesis of diabetes, heart disease, and kidney failure and may potentially affect skeletal muscle. Whether AGEs are associated with poor muscle strength is unknown. Methods. Serum carboxymethyl-lysine (CML), a dominant AGE, circulating soluble form of receptor for advanced glycation end products (sRAGE), and endogenous secretory receptor for advanced glycation end product (esRAGE) and grip strength were measured in 559 moderately to severely disabled women, age 65 and older, in the Women's Health and Aging Study I in Baltimore, Md. Results. Mean (standard deviation) grip strength among women in the highest quartile of serum CML compared with women in the lower three quartiles was 18.6 and 20.0 kg, respectively ( p =.002), adjusting for age, race, body mass index, cognitive dysfunction, depression, and diabetes. Serum sRAGE and esRAGE were not significantly associated with grip strength. Conclusions. Women with high serum AGEs have greater muscle weakness. Further studies are needed to determine whether AGEs, a potentially modifiable risk factor, are associated with physical performance and disability in older adults.
KW - Advanced glycation end products
KW - Aging
KW - Inflammation
KW - Muscle
KW - Sarcopenia
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U2 - 10.1093/gerona/gln018
DO - 10.1093/gerona/gln018
M3 - Article
C2 - 19182228
AN - SCOPUS:64249148929
SN - 1079-5006
VL - 64
SP - 132
EP - 137
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 1
ER -