Elevated preoperative Galectin-3 is associated with acute kidney injury after cardiac surgery

Moritz Wyler Von Ballmoos, Donald S. Likosky, Michael Rezaee, Kevin Lobdell, Shama Alam, Devin Parker, Sherry Owens, Heather Thiessen Philbrook, Todd MacKenzie, Jeremiah R. Brown

Research output: Contribution to journalArticle

Abstract

Background: Previous research suggests that novel biomarkers may be used to identify patients at increased risk of acute kidney injury following cardiac surgery. The purpose of this study was to evaluate the relationship between preoperative levels of circulating Galectin-3 (Gal-3) and acute kidney injury after cardiac surgery. Methods: Preoperative serum Gal-3 was measured in 1498 patients who underwent coronary artery bypass graft (CABG) surgery and/or valve surgery as part of the Northern New England Biomarker Study between 2004 and 2007. Preoperative Gal-3 levels were measured using multiplex assays and grouped into terciles. Univariate and multinomial logistic regression was used to assess the predictive ability of Gal-3 terciles and AKI occurrence and severity. Results: Before adjustment, patients in the highest tercile of Gal-3 had a 2.86-greater odds of developing postoperative KDIGO Stage 2 or 3 (p < 0.001) and 1.70-greater odds of developing KDIGO Stage 1 (p = < 0.001), compared to the first tercile. After adjustment, patients in the highest tercile had 2.95-greater odds of developing KDIGO Stage 2 or 3 (p < 0.001) and 1.71-increased odds of developing KDIGO Stage 1 (p = 0.001), compared to the first tercile. Compared to the base model, the addition of Gal-3 terciles improved discriminatory power compared to without Gal-3 terciles (test of equality = 0.042). Conclusion: Elevated preoperative Gal-3 levels significantly improves predictive ability over existing clinical models for postoperative AKI and may be used to augment risk information for patients at the highest risk of developing AKI and AKI severity after cardiac surgery.

Original languageEnglish (US)
Article number280
JournalBMC Nephrology
Volume19
Issue number1
DOIs
StatePublished - Oct 20 2018

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Galectin 3
Acute Kidney Injury
Thoracic Surgery
Biomarkers
New England
Coronary Artery Bypass
Logistic Models
Transplants

Keywords

  • Acute kidney injury (AKI)
  • Biomarkers
  • Cardiac surgery
  • Galectin-3 (Gal-3)
  • Prediction

ASJC Scopus subject areas

  • Nephrology

Cite this

Wyler Von Ballmoos, M., Likosky, D. S., Rezaee, M., Lobdell, K., Alam, S., Parker, D., ... Brown, J. R. (2018). Elevated preoperative Galectin-3 is associated with acute kidney injury after cardiac surgery. BMC Nephrology, 19(1), [280]. https://doi.org/10.1186/s12882-018-1093-0

Elevated preoperative Galectin-3 is associated with acute kidney injury after cardiac surgery. / Wyler Von Ballmoos, Moritz; Likosky, Donald S.; Rezaee, Michael; Lobdell, Kevin; Alam, Shama; Parker, Devin; Owens, Sherry; Thiessen Philbrook, Heather; MacKenzie, Todd; Brown, Jeremiah R.

In: BMC Nephrology, Vol. 19, No. 1, 280, 20.10.2018.

Research output: Contribution to journalArticle

Wyler Von Ballmoos, M, Likosky, DS, Rezaee, M, Lobdell, K, Alam, S, Parker, D, Owens, S, Thiessen Philbrook, H, MacKenzie, T & Brown, JR 2018, 'Elevated preoperative Galectin-3 is associated with acute kidney injury after cardiac surgery', BMC Nephrology, vol. 19, no. 1, 280. https://doi.org/10.1186/s12882-018-1093-0
Wyler Von Ballmoos M, Likosky DS, Rezaee M, Lobdell K, Alam S, Parker D et al. Elevated preoperative Galectin-3 is associated with acute kidney injury after cardiac surgery. BMC Nephrology. 2018 Oct 20;19(1). 280. https://doi.org/10.1186/s12882-018-1093-0
Wyler Von Ballmoos, Moritz ; Likosky, Donald S. ; Rezaee, Michael ; Lobdell, Kevin ; Alam, Shama ; Parker, Devin ; Owens, Sherry ; Thiessen Philbrook, Heather ; MacKenzie, Todd ; Brown, Jeremiah R. / Elevated preoperative Galectin-3 is associated with acute kidney injury after cardiac surgery. In: BMC Nephrology. 2018 ; Vol. 19, No. 1.
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abstract = "Background: Previous research suggests that novel biomarkers may be used to identify patients at increased risk of acute kidney injury following cardiac surgery. The purpose of this study was to evaluate the relationship between preoperative levels of circulating Galectin-3 (Gal-3) and acute kidney injury after cardiac surgery. Methods: Preoperative serum Gal-3 was measured in 1498 patients who underwent coronary artery bypass graft (CABG) surgery and/or valve surgery as part of the Northern New England Biomarker Study between 2004 and 2007. Preoperative Gal-3 levels were measured using multiplex assays and grouped into terciles. Univariate and multinomial logistic regression was used to assess the predictive ability of Gal-3 terciles and AKI occurrence and severity. Results: Before adjustment, patients in the highest tercile of Gal-3 had a 2.86-greater odds of developing postoperative KDIGO Stage 2 or 3 (p < 0.001) and 1.70-greater odds of developing KDIGO Stage 1 (p = < 0.001), compared to the first tercile. After adjustment, patients in the highest tercile had 2.95-greater odds of developing KDIGO Stage 2 or 3 (p < 0.001) and 1.71-increased odds of developing KDIGO Stage 1 (p = 0.001), compared to the first tercile. Compared to the base model, the addition of Gal-3 terciles improved discriminatory power compared to without Gal-3 terciles (test of equality = 0.042). Conclusion: Elevated preoperative Gal-3 levels significantly improves predictive ability over existing clinical models for postoperative AKI and may be used to augment risk information for patients at the highest risk of developing AKI and AKI severity after cardiac surgery.",
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AU - Parker, Devin

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