Elevated Platelet‐Associated IgG in PIA1‐Negative Mothers following Sensitization to the PIA1 Antigen during Pregnancy

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Between 1984 and 1990, we studied 25 infants with neonatal alloimmune thrombocytopenia caused by alloimmunization to the PIA1 alloantigen. We investigated whether mothers of these infants developed elevated platelet‐associated immunoglobulin (PAIgG) in addition to anti‐PIA1. Eight of the women were found to have PAIgG which persistet at least 7–10 days postdelivery. Eluates prepared from six of the women's platelets reacted with PIA1‐positive and PIA1‐negative donor platelets, and platelets from donors with Glanzmann's thrombasthenia. None of the women with elevated PAIgG had thrombocytopenia, eclampsia, or infections. Two women were found to have autereactive antibodies present in plasma. These results indicate that elevated PAIgG may be found in women immunized to the PIA1 antigen. Some women may also have autoreactive antiplatelet antibodies in their plasma. These findings may lead to confusing serologic findings in evaluating the cause of neonatal alloimmune thrombocytopenia.

Original languageEnglish (US)
Pages (from-to)210-214
Number of pages5
JournalVox sanguinis
Issue number3
StatePublished - Oct 1992

ASJC Scopus subject areas

  • Hematology

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