Elevated plasma long pentraxin-3 levels and primary graft dysfunction after lung transplantation for idiopathic pulmonary fibrosis

J. M. Diamond, D. J. Lederer, S. M. Kawut, J. Lee, V. N. Ahya, S. Bellamy, S. M. Palmer, V. N. Lama, S. Bhorade, M. Crespo, E. Demissie, J. Sonett, K. Wille, Jonathan B Orens, Pali Dedhiya Shah, A. Weinacker, D. Weill, B. A. Kohl, C. C. Deutschman, S. Arcasoy & 6 others A. S. Shah, J. A. Belperio, D. Wilkes, J. M. Reynolds, L. B. Ware, J. D. Christie

Research output: Contribution to journalArticle

Abstract

Primary graft dysfunction (PGD) after lung transplantation may result from ischemia reperfusion injury (IRI). The innate immune response to IRI may be mediated by Toll-like receptor and IL-1-induced long pentraxin-3 (PTX3) release. We hypothesized that elevated PTX3 levels were associated with PGD. We performed a nested case control study of lung transplant recipients with idiopathic pulmonary fibrosis (IPF) or chronic obstructive pulmonary disease (COPD) from the Lung Transplant Outcomes Group cohort. PTX3 levels were measured pretransplant, and 6 and 24 h postreperfusion. Caseswere subjects with grade 3 PGDwithin 72 h of transplantation and controls were those without grade 3 PGD. Generalized estimating equations and multivariable logistic regression were used for analysis. We selected 40 PGD cases and 79 non-PGD controls. Plasma PTX3 level was associated with PGD in IPF but not COPD recipients (p for interaction > 0.03). Among patients with IPF, PTX3 levels at 6 and 24 h were associated with PGD (OR = 1.6, p = 0.02 at 6 h; OR = 1.4, p = 0.008 at 24 h). Elevated PTX3 levels were associated with the development of PGD after lung transplantation in IPF patients. Future studies evaluating the role of innate immune activation in IPF and PGD are warranted.

Original languageEnglish (US)
Pages (from-to)2517-2522
Number of pages6
JournalAmerican Journal of Transplantation
Volume11
Issue number11
DOIs
StatePublished - Nov 2011

Fingerprint

Primary Graft Dysfunction
Idiopathic Pulmonary Fibrosis
Lung Transplantation
Reperfusion Injury
Chronic Obstructive Pulmonary Disease
Toll-Like Receptor 1
Transplants
Lung
PTX3 protein
Interleukin-1
Innate Immunity
Case-Control Studies
Transplantation
Logistic Models

Keywords

  • Idiopathic pulmonary fibrosis
  • Long pentraxin-3
  • Lung transplantation
  • Primary graft dysfunction

ASJC Scopus subject areas

  • Transplantation
  • Immunology and Allergy
  • Pharmacology (medical)

Cite this

Elevated plasma long pentraxin-3 levels and primary graft dysfunction after lung transplantation for idiopathic pulmonary fibrosis. / Diamond, J. M.; Lederer, D. J.; Kawut, S. M.; Lee, J.; Ahya, V. N.; Bellamy, S.; Palmer, S. M.; Lama, V. N.; Bhorade, S.; Crespo, M.; Demissie, E.; Sonett, J.; Wille, K.; Orens, Jonathan B; Shah, Pali Dedhiya; Weinacker, A.; Weill, D.; Kohl, B. A.; Deutschman, C. C.; Arcasoy, S.; Shah, A. S.; Belperio, J. A.; Wilkes, D.; Reynolds, J. M.; Ware, L. B.; Christie, J. D.

In: American Journal of Transplantation, Vol. 11, No. 11, 11.2011, p. 2517-2522.

Research output: Contribution to journalArticle

Diamond, JM, Lederer, DJ, Kawut, SM, Lee, J, Ahya, VN, Bellamy, S, Palmer, SM, Lama, VN, Bhorade, S, Crespo, M, Demissie, E, Sonett, J, Wille, K, Orens, JB, Shah, PD, Weinacker, A, Weill, D, Kohl, BA, Deutschman, CC, Arcasoy, S, Shah, AS, Belperio, JA, Wilkes, D, Reynolds, JM, Ware, LB & Christie, JD 2011, 'Elevated plasma long pentraxin-3 levels and primary graft dysfunction after lung transplantation for idiopathic pulmonary fibrosis', American Journal of Transplantation, vol. 11, no. 11, pp. 2517-2522. https://doi.org/10.1111/j.1600-6143.2011.03702.x
Diamond, J. M. ; Lederer, D. J. ; Kawut, S. M. ; Lee, J. ; Ahya, V. N. ; Bellamy, S. ; Palmer, S. M. ; Lama, V. N. ; Bhorade, S. ; Crespo, M. ; Demissie, E. ; Sonett, J. ; Wille, K. ; Orens, Jonathan B ; Shah, Pali Dedhiya ; Weinacker, A. ; Weill, D. ; Kohl, B. A. ; Deutschman, C. C. ; Arcasoy, S. ; Shah, A. S. ; Belperio, J. A. ; Wilkes, D. ; Reynolds, J. M. ; Ware, L. B. ; Christie, J. D. / Elevated plasma long pentraxin-3 levels and primary graft dysfunction after lung transplantation for idiopathic pulmonary fibrosis. In: American Journal of Transplantation. 2011 ; Vol. 11, No. 11. pp. 2517-2522.
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AU - Diamond, J. M.

AU - Lederer, D. J.

AU - Kawut, S. M.

AU - Lee, J.

AU - Ahya, V. N.

AU - Bellamy, S.

AU - Palmer, S. M.

AU - Lama, V. N.

AU - Bhorade, S.

AU - Crespo, M.

AU - Demissie, E.

AU - Sonett, J.

AU - Wille, K.

AU - Orens, Jonathan B

AU - Shah, Pali Dedhiya

AU - Weinacker, A.

AU - Weill, D.

AU - Kohl, B. A.

AU - Deutschman, C. C.

AU - Arcasoy, S.

AU - Shah, A. S.

AU - Belperio, J. A.

AU - Wilkes, D.

AU - Reynolds, J. M.

AU - Ware, L. B.

AU - Christie, J. D.

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