Elevated plasma amyloid β-peptide 1-42 and onset of dementia in adults with Down syndrome

Nicole Schupf, Bindu Patel, Wayne Silverman, Warren B. Zigman, Nan Zhong, Benjamin Tycko, Pankaj D. Mehta, Richard Mayeux

Research output: Contribution to journalArticle

Abstract

We compared levels of plasma amyloid β-peptides Aβ1-42 and Aβ1-40 in 108 demented and nondemented adults with Down syndrome (DS) and 64 adults from the general population. Aβ1-42 and Aβ1-40 levels were significantly higher in adults with DS than in controls (P = 0.0001). Compared to nondemented adults with DS, Aβ1-42 levels in demented adults with DS were selectively increased by 26% (28.2 pg/ml vs. 22.4 pg/ml, P = 0.004). In addition, mean plasma levels of Aβ1-42 were 22% higher in DS cases with the apolipoprotein ε4 allele than in DS subjects without an ε4 allele (25.9 pg/ml vs. 21.2 pg/ml, P = 0.01), while mean plasma levels of Aβ1-40 did not vary by APOE genotype. These results support the hypothesis that Aβ1-42 plays an important role in the pathogenesis of dementia associated with DS, as it does in Alzheimer's disease, and that variations in plasma levels may be related to disease progression.

Original languageEnglish (US)
Pages (from-to)199-203
Number of pages5
JournalNeuroscience Letters
Volume301
Issue number3
DOIs
StatePublished - Apr 6 2001

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • Beta amyloid 1-42
  • Blood plasma
  • Down syndrome

ASJC Scopus subject areas

  • Neuroscience(all)

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    Schupf, N., Patel, B., Silverman, W., Zigman, W. B., Zhong, N., Tycko, B., Mehta, P. D., & Mayeux, R. (2001). Elevated plasma amyloid β-peptide 1-42 and onset of dementia in adults with Down syndrome. Neuroscience Letters, 301(3), 199-203. https://doi.org/10.1016/S0304-3940(01)01657-3