Elevated pain sensitivity in chronic pain patients at risk for opioid misuse

Robert R. Edwards, Ajay D. Wasan, Ed Michna, Seth Greenbaum, Ed Ross, Robert N. Jamison

Research output: Contribution to journalArticlepeer-review


This study employed quantitative sensory testing (QST) to evaluate pain responses in chronic spinal pain patients at low risk and high risk for opioid misuse, with risk classification based on scores on the Screener and Opioid Assessment for Patients with Pain-Revised (SOAPP-R). Patients were further subgrouped according to current use of prescription opioids. Of the 276 chronic pain patients tested, approximately 65% were taking opioids; a median split was used to further categorize these patients as being on lower or higher doses of opioids. The high-risk group (n = 161) reported higher levels of clinical pain, had lower pressure and thermal pain thresholds at multiple body sites, had lower heat pain tolerance, and rated repetitive mechanical stimuli as more painful relative to the low-risk group (n = 115; P's

Original languageEnglish (US)
Pages (from-to)953-963
Number of pages11
JournalJournal of Pain
Issue number9
StatePublished - Sep 2011
Externally publishedYes


  • anxiety
  • catastrophizing
  • chronic pain
  • Hyperalgesia
  • opioid misuse

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Neurology
  • Clinical Neurology


Dive into the research topics of 'Elevated pain sensitivity in chronic pain patients at risk for opioid misuse'. Together they form a unique fingerprint.

Cite this