Elevated NT-pro-BNP levels are associated with comorbidities among HIV-infected women

Ather Mansoor, Keri Althoff, Stephen J Gange, Kathryn Anastos, Jack Dehovitz, Howard Minkoff, Robert Kaplan, Susan Holman, Jason M. Lazar

Research output: Contribution to journalArticle

Abstract

HIV infection is associated with left ventricular (LV) dysfunction and accelerated atherosclerosis. These conditions result in elevation of plasma natriuretic peptide (NP) levels. The present study compares N-terminal-pro-BNP (NT-pro-BNP) levels in HIV-infected and -uninfected women and identifies factors influencing NT-pro-BNP levels in HIV-infected women. A total of 454 HIV-infected and 200 HIV-uninfected participants from the Women's Interagency HIV Study (WIHS) had NT-pro-BNP determination. Elevated NT-pro-BNP level was defined using previously determined age stratified cut-off values of > 164 ng/liter (age 225 (age ≥ 60 years). HIV-infected women were older (41.6 ± 8.9 vs. 38.9±10.5 years, p <0.01) and were more likely to have anemia, hepatitis C virus (HCV) antibodies, and kidney dysfunction than HIV-uninfected women. HIV-infected women had significantly higher NT-pro-BNP levels (142.4 ± 524.8 vs. 73.6 ± 115.1 ng/liter, p = 0.01) and a higher prevalence of elevated NT-pro-BNP (12.1% vs. 7.5%; p= 0.08). In univariate analyses, elevated NT-pro-BNP was significantly associated with age, systolic BP, hypertension, anemia, triglyceride levels, kidney disease, and HCV seropositivity, but not HIV infection. In multivariate analysis, elevated NT-pro-BNP levels were significantly associated with anemia and kidney function, and had a borderline association with the presence of HCV antibodies. Among HIV-infected women, NT-pro-BNP levels were not independently associated with measures of severity of infection or with HAART use. Although HIV-infected women have higher NT-pro-BNP levels than HIV-uninfected women, the differences are due to non-HIV factors such as anemia, kidney disease, and HCV coinfection. These findings suggest that natriuretic peptide levels are a global marker of comorbidity in the setting of HIV infection.

Original languageEnglish (US)
Pages (from-to)997-1004
Number of pages8
JournalAIDS Research and Human Retroviruses
Volume25
Issue number10
DOIs
StatePublished - Oct 1 2009

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ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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