Elevated Microparticle Tissue Factor Activity Is Associated With Carotid Artery Plaque in HIV-Infected Women

Juan Lin, Xiaonan Xue, Kathryn Anastos, Mardge H. Cohen, Stephen J Gange, Jason M. Lazar, Chenglong Liu, Wendy J. Mack, Phyllis C. Tien, Cathy Tilley, Howard N. Hodis, Alan L. Landay, Russell P. Tracy, Robert C. Kaplan, David B. Hanna

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Expression of tissue factor (TF) on the surface of activated monocytes may trigger thrombosis, leading to clotting risk, inflammation, and atherosclerosis. TF-positive microparticles (MP-TF) represent a functionally active form of TF that may be promulgated by long-term HIV infection. We hypothesized that greater MP-TF activity is associated with carotid artery plaque in HIV+ women. SETTING: In a case-control study nested within the Women's Interagency HIV Study (WIHS), eligible HIV+ participants underwent B-mode carotid artery ultrasound at 2 study visits occurring 7 years apart. Cases were defined by the presence of at least 1 carotid artery plaque assessed at either visit. Cases were matched 1:2 to controls who were found not to have carotid artery plaques. METHODS: Conditional logistic regression estimated the association of MP-TF activity with the presence of carotid artery plaque, adjusting for demographic and behavioral characteristics, HIV-related factors, cardiometabolic risk factors, and serum inflammation biomarkers (high-sensitivity C-reactive protein, IL-6, sCD14, sCD163, Gal-3, and Gal-3BP). RESULTS: Elevated MP-TF activity (>0.537 pg/mL) was found to be significantly associated with greater odds of plaque (adjusted odds ratio 3.86, 95% confidence interval: 1.06 to 14.07, P = 0.04). The association was attenuated after further adjustment for IL-6 but was unaffected by adjustment for other biomarkers including those denoting monocyte activation. CONCLUSIONS: Our findings suggest a link among HIV infection, innate immune system perturbation, coagulation, and atherosclerosis.

Original languageEnglish (US)
Pages (from-to)36-43
Number of pages8
JournalJournal of acquired immune deficiency syndromes (1999)
Volume81
Issue number1
DOIs
StatePublished - May 1 2019

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Carotid Stenosis
Thromboplastin
HIV
HIV Infections
Monocytes
Interleukin-6
Atherosclerosis
Biomarkers
Inflammation
Carotid Arteries
C-Reactive Protein
Case-Control Studies
Immune System
Thrombosis
Logistic Models
Odds Ratio
Demography
Confidence Intervals
Serum

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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Elevated Microparticle Tissue Factor Activity Is Associated With Carotid Artery Plaque in HIV-Infected Women. / Lin, Juan; Xue, Xiaonan; Anastos, Kathryn; Cohen, Mardge H.; Gange, Stephen J; Lazar, Jason M.; Liu, Chenglong; Mack, Wendy J.; Tien, Phyllis C.; Tilley, Cathy; Hodis, Howard N.; Landay, Alan L.; Tracy, Russell P.; Kaplan, Robert C.; Hanna, David B.

In: Journal of acquired immune deficiency syndromes (1999), Vol. 81, No. 1, 01.05.2019, p. 36-43.

Research output: Contribution to journalArticle

Lin, J, Xue, X, Anastos, K, Cohen, MH, Gange, SJ, Lazar, JM, Liu, C, Mack, WJ, Tien, PC, Tilley, C, Hodis, HN, Landay, AL, Tracy, RP, Kaplan, RC & Hanna, DB 2019, 'Elevated Microparticle Tissue Factor Activity Is Associated With Carotid Artery Plaque in HIV-Infected Women', Journal of acquired immune deficiency syndromes (1999), vol. 81, no. 1, pp. 36-43. https://doi.org/10.1097/QAI.0000000000001988
Lin, Juan ; Xue, Xiaonan ; Anastos, Kathryn ; Cohen, Mardge H. ; Gange, Stephen J ; Lazar, Jason M. ; Liu, Chenglong ; Mack, Wendy J. ; Tien, Phyllis C. ; Tilley, Cathy ; Hodis, Howard N. ; Landay, Alan L. ; Tracy, Russell P. ; Kaplan, Robert C. ; Hanna, David B. / Elevated Microparticle Tissue Factor Activity Is Associated With Carotid Artery Plaque in HIV-Infected Women. In: Journal of acquired immune deficiency syndromes (1999). 2019 ; Vol. 81, No. 1. pp. 36-43.
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AU - Lin, Juan

AU - Xue, Xiaonan

AU - Anastos, Kathryn

AU - Cohen, Mardge H.

AU - Gange, Stephen J

AU - Lazar, Jason M.

AU - Liu, Chenglong

AU - Mack, Wendy J.

AU - Tien, Phyllis C.

AU - Tilley, Cathy

AU - Hodis, Howard N.

AU - Landay, Alan L.

AU - Tracy, Russell P.

AU - Kaplan, Robert C.

AU - Hanna, David B.

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N2 - BACKGROUND: Expression of tissue factor (TF) on the surface of activated monocytes may trigger thrombosis, leading to clotting risk, inflammation, and atherosclerosis. TF-positive microparticles (MP-TF) represent a functionally active form of TF that may be promulgated by long-term HIV infection. We hypothesized that greater MP-TF activity is associated with carotid artery plaque in HIV+ women. SETTING: In a case-control study nested within the Women's Interagency HIV Study (WIHS), eligible HIV+ participants underwent B-mode carotid artery ultrasound at 2 study visits occurring 7 years apart. Cases were defined by the presence of at least 1 carotid artery plaque assessed at either visit. Cases were matched 1:2 to controls who were found not to have carotid artery plaques. METHODS: Conditional logistic regression estimated the association of MP-TF activity with the presence of carotid artery plaque, adjusting for demographic and behavioral characteristics, HIV-related factors, cardiometabolic risk factors, and serum inflammation biomarkers (high-sensitivity C-reactive protein, IL-6, sCD14, sCD163, Gal-3, and Gal-3BP). RESULTS: Elevated MP-TF activity (>0.537 pg/mL) was found to be significantly associated with greater odds of plaque (adjusted odds ratio 3.86, 95% confidence interval: 1.06 to 14.07, P = 0.04). The association was attenuated after further adjustment for IL-6 but was unaffected by adjustment for other biomarkers including those denoting monocyte activation. CONCLUSIONS: Our findings suggest a link among HIV infection, innate immune system perturbation, coagulation, and atherosclerosis.

AB - BACKGROUND: Expression of tissue factor (TF) on the surface of activated monocytes may trigger thrombosis, leading to clotting risk, inflammation, and atherosclerosis. TF-positive microparticles (MP-TF) represent a functionally active form of TF that may be promulgated by long-term HIV infection. We hypothesized that greater MP-TF activity is associated with carotid artery plaque in HIV+ women. SETTING: In a case-control study nested within the Women's Interagency HIV Study (WIHS), eligible HIV+ participants underwent B-mode carotid artery ultrasound at 2 study visits occurring 7 years apart. Cases were defined by the presence of at least 1 carotid artery plaque assessed at either visit. Cases were matched 1:2 to controls who were found not to have carotid artery plaques. METHODS: Conditional logistic regression estimated the association of MP-TF activity with the presence of carotid artery plaque, adjusting for demographic and behavioral characteristics, HIV-related factors, cardiometabolic risk factors, and serum inflammation biomarkers (high-sensitivity C-reactive protein, IL-6, sCD14, sCD163, Gal-3, and Gal-3BP). RESULTS: Elevated MP-TF activity (>0.537 pg/mL) was found to be significantly associated with greater odds of plaque (adjusted odds ratio 3.86, 95% confidence interval: 1.06 to 14.07, P = 0.04). The association was attenuated after further adjustment for IL-6 but was unaffected by adjustment for other biomarkers including those denoting monocyte activation. CONCLUSIONS: Our findings suggest a link among HIV infection, innate immune system perturbation, coagulation, and atherosclerosis.

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