Elevated Levels of Peripheral Serum Creatine Phosphokinase With Strangulated Small Bowel Obstruction

Geoffrey M. Graeber, John F. O'Neill, Robert E. Wolf, Dane K. Wukich, Patrick J. Cafferty, John Harmon

Research output: Contribution to journalArticle

Abstract

Experimental arterial bowel infarction can cause elevetions in levels of peripheral serum creatine phosphokinase (CPK), lactic dehydrogenase (LDH), and their isoenzymes. To test whether these changes would occur in strangulated small bowel infarctions, 18 dogs were placed under general anesthesia and randomized to one of three categories: laparotomy alone, simple mechanical small bowel obstruction, or strangulated small bowel infarction induced by incarcerating bowel in a surgically created ventral hernia. Serum samples were drawn for 48 hours postoperatively. Total CPK and LDH activity were determined by automated spectrophotometry; isoenzyme levels were determined by agarose gel electrophoresis. Levels of peripheral serum CPK and each of its isoenzymes became significantly elevated in the dogs with strangulated infarction. Such elevations did not occur with LDH. The findings suggest that changes in peripheral serum CPK could prove helpful in evaluating bowel viability in cases of intestinal obstruction.

Original languageEnglish (US)
Pages (from-to)837-840
Number of pages4
JournalArchives of Surgery
Volume118
Issue number7
DOIs
StatePublished - 1983
Externally publishedYes

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Creatine Kinase
Infarction
Isoenzymes
Oxidoreductases
Milk
Serum
Dogs
Ventral Hernia
Agar Gel Electrophoresis
Intestinal Obstruction
Spectrophotometry
Laparotomy
General Anesthesia

ASJC Scopus subject areas

  • Surgery

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Elevated Levels of Peripheral Serum Creatine Phosphokinase With Strangulated Small Bowel Obstruction. / Graeber, Geoffrey M.; O'Neill, John F.; Wolf, Robert E.; Wukich, Dane K.; Cafferty, Patrick J.; Harmon, John.

In: Archives of Surgery, Vol. 118, No. 7, 1983, p. 837-840.

Research output: Contribution to journalArticle

Graeber, Geoffrey M. ; O'Neill, John F. ; Wolf, Robert E. ; Wukich, Dane K. ; Cafferty, Patrick J. ; Harmon, John. / Elevated Levels of Peripheral Serum Creatine Phosphokinase With Strangulated Small Bowel Obstruction. In: Archives of Surgery. 1983 ; Vol. 118, No. 7. pp. 837-840.
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