Abstract
The aging of the human immunodeficiency virus type 1 (HIV- 1)-infected population obligates a focus on the interaction between aging, comorbid conditions, and HIV-1. We recruited a cohort of HIV-1-infected men aged ≤35 years or ≥50 years who were receiving fully suppressive antiretroviral therapy (ART). We analyzed plasma markers of inflammation; T-cell activation, exhaustion, proliferation; and innate cellular subsets and functional capacity. Levels of lipopolysaccharide and the plasma marker of chemokine (C-C motif ) ligand 2 were significantly elevated in older HIV-infected men despite comparable cellular phenotypes. Compared with similarly age-stratified uninfected subjects, older HIV-1-infected adults were also more frequently in the upper quartile of soluble CD14 expression.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 771-775 |
| Number of pages | 5 |
| Journal | Journal of Infectious Diseases |
| Volume | 212 |
| Issue number | 11 |
| DOIs | |
| State | Published - 2016 |
| Externally published | Yes |
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Keywords
- Chemokine
- HIV-1
- Inflammation
- Monocytes
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases
Cite this
Elevated levels of microbial translocation markers and CCL2 among older HIV-1-infected men. / Scully, Eileen; Lockhart, Ainsley; Huang, Lisa; Robles, Yvonne; Becerril, Carlos; Romero-Tejeda, Marisol; Albrecht, Mary A.; Palmer, Christine D.; Bosch, Ronald J.; Altfeld, Marcus; Kuritzkes, Daniel R.; Lin, Nina H.
In: Journal of Infectious Diseases, Vol. 212, No. 11, 2016, p. 771-775.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Elevated levels of microbial translocation markers and CCL2 among older HIV-1-infected men
AU - Scully, Eileen
AU - Lockhart, Ainsley
AU - Huang, Lisa
AU - Robles, Yvonne
AU - Becerril, Carlos
AU - Romero-Tejeda, Marisol
AU - Albrecht, Mary A.
AU - Palmer, Christine D.
AU - Bosch, Ronald J.
AU - Altfeld, Marcus
AU - Kuritzkes, Daniel R.
AU - Lin, Nina H.
PY - 2016
Y1 - 2016
N2 - The aging of the human immunodeficiency virus type 1 (HIV- 1)-infected population obligates a focus on the interaction between aging, comorbid conditions, and HIV-1. We recruited a cohort of HIV-1-infected men aged ≤35 years or ≥50 years who were receiving fully suppressive antiretroviral therapy (ART). We analyzed plasma markers of inflammation; T-cell activation, exhaustion, proliferation; and innate cellular subsets and functional capacity. Levels of lipopolysaccharide and the plasma marker of chemokine (C-C motif ) ligand 2 were significantly elevated in older HIV-infected men despite comparable cellular phenotypes. Compared with similarly age-stratified uninfected subjects, older HIV-1-infected adults were also more frequently in the upper quartile of soluble CD14 expression.
AB - The aging of the human immunodeficiency virus type 1 (HIV- 1)-infected population obligates a focus on the interaction between aging, comorbid conditions, and HIV-1. We recruited a cohort of HIV-1-infected men aged ≤35 years or ≥50 years who were receiving fully suppressive antiretroviral therapy (ART). We analyzed plasma markers of inflammation; T-cell activation, exhaustion, proliferation; and innate cellular subsets and functional capacity. Levels of lipopolysaccharide and the plasma marker of chemokine (C-C motif ) ligand 2 were significantly elevated in older HIV-infected men despite comparable cellular phenotypes. Compared with similarly age-stratified uninfected subjects, older HIV-1-infected adults were also more frequently in the upper quartile of soluble CD14 expression.
KW - Chemokine
KW - HIV-1
KW - Inflammation
KW - Monocytes
UR - http://www.scopus.com/inward/record.url?scp=84958645173&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84958645173&partnerID=8YFLogxK
U2 - 10.1093/infdis/jiv501
DO - 10.1093/infdis/jiv501
M3 - Article
C2 - 26494772
AN - SCOPUS:84958645173
VL - 212
SP - 771
EP - 775
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 11
ER -