Elevated levels of microbial translocation markers and CCL2 among older HIV-1-infected men

Eileen Scully, Ainsley Lockhart, Lisa Huang, Yvonne Robles, Carlos Becerril, Marisol Romero-Tejeda, Mary A. Albrecht, Christine D. Palmer, Ronald J. Bosch, Marcus Altfeld, Daniel R. Kuritzkes, Nina H. Lin

Research output: Contribution to journalArticle

Abstract

The aging of the human immunodeficiency virus type 1 (HIV- 1)-infected population obligates a focus on the interaction between aging, comorbid conditions, and HIV-1. We recruited a cohort of HIV-1-infected men aged ≤35 years or ≥50 years who were receiving fully suppressive antiretroviral therapy (ART). We analyzed plasma markers of inflammation; T-cell activation, exhaustion, proliferation; and innate cellular subsets and functional capacity. Levels of lipopolysaccharide and the plasma marker of chemokine (C-C motif ) ligand 2 were significantly elevated in older HIV-infected men despite comparable cellular phenotypes. Compared with similarly age-stratified uninfected subjects, older HIV-1-infected adults were also more frequently in the upper quartile of soluble CD14 expression.

Original languageEnglish (US)
Pages (from-to)771-775
Number of pages5
JournalJournal of Infectious Diseases
Volume212
Issue number11
DOIs
StatePublished - 2016
Externally publishedYes

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HIV-1
Chemokine CCL2
Lipopolysaccharides
HIV
Inflammation
T-Lymphocytes
Phenotype
Population
Therapeutics

Keywords

  • Chemokine
  • HIV-1
  • Inflammation
  • Monocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Scully, E., Lockhart, A., Huang, L., Robles, Y., Becerril, C., Romero-Tejeda, M., ... Lin, N. H. (2016). Elevated levels of microbial translocation markers and CCL2 among older HIV-1-infected men. Journal of Infectious Diseases, 212(11), 771-775. https://doi.org/10.1093/infdis/jiv501

Elevated levels of microbial translocation markers and CCL2 among older HIV-1-infected men. / Scully, Eileen; Lockhart, Ainsley; Huang, Lisa; Robles, Yvonne; Becerril, Carlos; Romero-Tejeda, Marisol; Albrecht, Mary A.; Palmer, Christine D.; Bosch, Ronald J.; Altfeld, Marcus; Kuritzkes, Daniel R.; Lin, Nina H.

In: Journal of Infectious Diseases, Vol. 212, No. 11, 2016, p. 771-775.

Research output: Contribution to journalArticle

Scully, E, Lockhart, A, Huang, L, Robles, Y, Becerril, C, Romero-Tejeda, M, Albrecht, MA, Palmer, CD, Bosch, RJ, Altfeld, M, Kuritzkes, DR & Lin, NH 2016, 'Elevated levels of microbial translocation markers and CCL2 among older HIV-1-infected men', Journal of Infectious Diseases, vol. 212, no. 11, pp. 771-775. https://doi.org/10.1093/infdis/jiv501
Scully, Eileen ; Lockhart, Ainsley ; Huang, Lisa ; Robles, Yvonne ; Becerril, Carlos ; Romero-Tejeda, Marisol ; Albrecht, Mary A. ; Palmer, Christine D. ; Bosch, Ronald J. ; Altfeld, Marcus ; Kuritzkes, Daniel R. ; Lin, Nina H. / Elevated levels of microbial translocation markers and CCL2 among older HIV-1-infected men. In: Journal of Infectious Diseases. 2016 ; Vol. 212, No. 11. pp. 771-775.
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