@article{0c4ae3495bf444bc8eb3c7b44ccf7204,
title = "Elevated levels of microbial translocation markers and CCL2 among older HIV-1-infected men",
abstract = "The aging of the human immunodeficiency virus type 1 (HIV- 1)-infected population obligates a focus on the interaction between aging, comorbid conditions, and HIV-1. We recruited a cohort of HIV-1-infected men aged ≤35 years or ≥50 years who were receiving fully suppressive antiretroviral therapy (ART). We analyzed plasma markers of inflammation; T-cell activation, exhaustion, proliferation; and innate cellular subsets and functional capacity. Levels of lipopolysaccharide and the plasma marker of chemokine (C-C motif ) ligand 2 were significantly elevated in older HIV-infected men despite comparable cellular phenotypes. Compared with similarly age-stratified uninfected subjects, older HIV-1-infected adults were also more frequently in the upper quartile of soluble CD14 expression.",
keywords = "Chemokine, HIV-1, Inflammation, Monocytes",
author = "Eileen Scully and Ainsley Lockhart and Lisa Huang and Yvonne Robles and Carlos Becerril and Marisol Romero-Tejeda and Albrecht, {Mary A.} and Palmer, {Christine D.} and Bosch, {Ronald J.} and Marcus Altfeld and Kuritzkes, {Daniel R.} and Lin, {Nina H.}",
note = "Funding Information: We thank all of the participants enrolled in the study; all of the human immunodeficiency virus physicians and nurses at Brigham and Women?s Hospital, Massachusetts General Hospital, Beth Israel Deaconess Hospital, and Fenway Health, for referral of eligible participants for this cohort; Andrea Kershaw, NP, for her assistance in screening and enrolling of participants for this study from the infectious diseases outpatient clinic at the Beth Israel Deaconess Medical Center; and Martin Hirsch and Manish Sagar, for their critical review of the draft manuscript. N. H. L. and E. S. served as the chief investigators. N. H. L. designed and implemented the clinical study, identified and enrolled the patient subgroups, and, together with E. S., designed, developed, and coordinated the experimental studies and interpreted the data. D. R. K. and M. A. provided scientific guidance, assistance with the experimental approaches, and clinical infrastructure for the clinical study. C. B., L. H., M. A. A., and Y. R. assisted with regulatory issues for the clinical cohort, patient recruitment, specimen collection, specimen processing, and analyses. A. L., M. R.-T., C. D. P., and L. H. performed the flow and immunological assays. E. S. performed the statistical analysis, with assistance and input from R. J. B. and N. H. L. N. H. L. and E. S. wrote and edited the manuscript. This work was supported by the National Institute of Allergy and Infectious Diseases (grant 5 K08 AI081545 to N. H. L.); the Harvard University Center for AIDS Research, a National Institutes of Health (NIH)?funded program (grant P30 A1060354; supplemental award to N. H. L.); and the Ragon Institute Immune Monitoring Core and NIH (grant P01 AI074415).",
year = "2015",
doi = "10.1093/infdis/jiv501",
language = "English (US)",
volume = "212",
pages = "771--775",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "11",
}