Elevated levels of microbial translocation markers and CCL2 among older HIV-1-infected men

Eileen Scully, Ainsley Lockhart, Lisa Huang, Yvonne Robles, Carlos Becerril, Marisol Romero-Tejeda, Mary A. Albrecht, Christine D. Palmer, Ronald J. Bosch, Marcus Altfeld, Daniel R. Kuritzkes, Nina H. Lin

Research output: Contribution to journalArticlepeer-review

Abstract

The aging of the human immunodeficiency virus type 1 (HIV- 1)-infected population obligates a focus on the interaction between aging, comorbid conditions, and HIV-1. We recruited a cohort of HIV-1-infected men aged ≤35 years or ≥50 years who were receiving fully suppressive antiretroviral therapy (ART). We analyzed plasma markers of inflammation; T-cell activation, exhaustion, proliferation; and innate cellular subsets and functional capacity. Levels of lipopolysaccharide and the plasma marker of chemokine (C-C motif ) ligand 2 were significantly elevated in older HIV-infected men despite comparable cellular phenotypes. Compared with similarly age-stratified uninfected subjects, older HIV-1-infected adults were also more frequently in the upper quartile of soluble CD14 expression.

Original languageEnglish (US)
Pages (from-to)771-775
Number of pages5
JournalJournal of Infectious Diseases
Volume212
Issue number11
DOIs
StatePublished - 2015

Keywords

  • Chemokine
  • HIV-1
  • Inflammation
  • Monocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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