Elevated histaminase (diamine oxidase) activity in small cell carcinoma of the lung

Stephen B Baylin, M. D. Abeloff, K. C. Wieman, J. W. Tomford, David S Ettinger

Research output: Contribution to journalArticle

Abstract

To investigate the possible embryologic relation between small cell carcinoma of the lung and medullary thyroid carcinoma, the plasma histaminase (an enzyme found in medullary carcinoma tissue) in 25 patients with small cell tumors was measured. The assays used histamine and putrescine as substrates. Thirty two per per cent of the patients by the histamine assay, and 31% by the putrescine, had values greater than +2 S.D. from the mean for 63 normal persons. In contrast, among 20 patients with squamous and large cell lung tumors, one (by the histamine assay), and two (by the putrescine) had elevated values. In four of five autopsy cases, histaminase was high in small cell carcinoma tissue. The enzyme in plasma and in tumor behaved as classic histaminase in substrate specificity, and in response to inhibitors. The data support the proposed embryologic relation between small cell lung carcinoma and medullary thyroid carcinoma, and further associate histaminase with some neural crest tumors.

Original languageEnglish (US)
Pages (from-to)1286-1290
Number of pages5
JournalNew England Journal of Medicine
Volume293
Issue number25
StatePublished - 1975

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Amine Oxidase (Copper-Containing)
Small Cell Lung Carcinoma
Putrescine
Histamine
Neoplasms
Medullary Carcinoma
Small Cell Carcinoma
Enzymes
Substrate Specificity
Autopsy
Epithelial Cells
Lung
Medullary Thyroid cancer

ASJC Scopus subject areas

  • Medicine(all)

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Elevated histaminase (diamine oxidase) activity in small cell carcinoma of the lung. / Baylin, Stephen B; Abeloff, M. D.; Wieman, K. C.; Tomford, J. W.; Ettinger, David S.

In: New England Journal of Medicine, Vol. 293, No. 25, 1975, p. 1286-1290.

Research output: Contribution to journalArticle

Baylin, Stephen B ; Abeloff, M. D. ; Wieman, K. C. ; Tomford, J. W. ; Ettinger, David S. / Elevated histaminase (diamine oxidase) activity in small cell carcinoma of the lung. In: New England Journal of Medicine. 1975 ; Vol. 293, No. 25. pp. 1286-1290.
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