TY - JOUR
T1 - Elevated highly sensitive C-reactive protein and d-dimer levels are associated with food insecurity among people living with HIV in Pune, India
AU - Patil, Sandesh
AU - Kadam, Dileep
AU - Mehtani, Nicky
AU - Sangle, Shashikala
AU - Marbaniang, Ivan
AU - Kulkarni, Vandana
AU - Shere, Dhananjay
AU - Deshpande, Prasad
AU - Dhumal, Gauri
AU - Suryavanshi, Nishi
AU - Gupte, Nikhil
AU - Bollinger, Robert
AU - Deluca, Andrea
AU - Nevrekar, Neetal
AU - Menon, Pramila
AU - Kawade, Rama
AU - Patil, Mansi
AU - Gupta, Amita
AU - Mave, Vidya
N1 - Publisher Copyright:
© The Authors 2019.
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Objective To assess the prevalence and determinants of food insecurity among people living with HIV (PLWH) in Pune, India and its association with biomarkers known to confer increased risks of morbidity and mortality in this population.Design Cross-sectional analysis assessing food insecurity using the standardized Household Food Insecurity Access Scale. Participants were dichotomized into two groups: food insecure and food secure. Logistic regression models were used to assess associations between socio-economic, demographic, clinical, biochemical factors and food insecurity.Setting Antiretroviral therapy (ART) centre of Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals (BJGMC-SGH), Pune, a large publicly funded tertiary and teaching hospital in western India.Particpants Adult (≥18 years) PLWH attending the ART centre between September 2015 and May 2016 who had received ART for either ≤7d (ART-naïve) or ≥1 year (ART-experienced).Results Food insecurity was reported by 40 % of 483 participants. Independent risk factors (adjusted OR; 95 % CI) included monthly family income <INR 5000 (~70 USD; 13·2; CI 5·4, 32·2) and consuming ≥4 non-vegetarian meals per week (4·7; 1·9, 11·9). High-sensitivity C-reactive protein (hs-CRP) ≥0·33 mg/dl (1·6; 1·04, 2·6) and d-dimer levels 0·19-0·31 g/ml (1·6; 1·01, 2·6) and ≥0·32 g/ml (1·9; 1·2, 3·2) were also associated with food insecurity.Conclusions More than a third of the study participants were food insecure. Furthermore, higher hs-CRP and d-dimer levels were associated with food insecurity. Prospective studies are required to understand the relationship between food insecurity, hs-CRP and d-dimer better.
AB - Objective To assess the prevalence and determinants of food insecurity among people living with HIV (PLWH) in Pune, India and its association with biomarkers known to confer increased risks of morbidity and mortality in this population.Design Cross-sectional analysis assessing food insecurity using the standardized Household Food Insecurity Access Scale. Participants were dichotomized into two groups: food insecure and food secure. Logistic regression models were used to assess associations between socio-economic, demographic, clinical, biochemical factors and food insecurity.Setting Antiretroviral therapy (ART) centre of Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals (BJGMC-SGH), Pune, a large publicly funded tertiary and teaching hospital in western India.Particpants Adult (≥18 years) PLWH attending the ART centre between September 2015 and May 2016 who had received ART for either ≤7d (ART-naïve) or ≥1 year (ART-experienced).Results Food insecurity was reported by 40 % of 483 participants. Independent risk factors (adjusted OR; 95 % CI) included monthly family income <INR 5000 (~70 USD; 13·2; CI 5·4, 32·2) and consuming ≥4 non-vegetarian meals per week (4·7; 1·9, 11·9). High-sensitivity C-reactive protein (hs-CRP) ≥0·33 mg/dl (1·6; 1·04, 2·6) and d-dimer levels 0·19-0·31 g/ml (1·6; 1·01, 2·6) and ≥0·32 g/ml (1·9; 1·2, 3·2) were also associated with food insecurity.Conclusions More than a third of the study participants were food insecure. Furthermore, higher hs-CRP and d-dimer levels were associated with food insecurity. Prospective studies are required to understand the relationship between food insecurity, hs-CRP and d-dimer better.
KW - Food insecurity
KW - HIV
KW - High-sensitivity C-reactive protein
KW - India
KW - d-Dimer
UR - http://www.scopus.com/inward/record.url?scp=85062397746&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85062397746&partnerID=8YFLogxK
U2 - 10.1017/S136898001900020X
DO - 10.1017/S136898001900020X
M3 - Article
C2 - 30827288
AN - SCOPUS:85062397746
SN - 1368-9800
VL - 22
SP - 2022
EP - 2029
JO - Public health nutrition
JF - Public health nutrition
IS - 11
ER -