Elevated highly sensitive C-reactive protein and d-dimer levels are associated with food insecurity among people living with HIV in Pune, India

Sandesh Patil, Dileep Kadam, Nicky Mehtani, Shashikala Sangle, Ivan Marbaniang, Vandana Kulkarni, Dhananjay Shere, Prasad Deshpande, Gauri Dhumal, Nishi Suryavanshi, Nikhil Gupte, Robert C Bollinger, Andrea Deluca, Neetal Nevrekar, Pramila Menon, Rama Kawade, Mansi Patil, Amita Gupta, Vidya Mave

Research output: Contribution to journalArticle

Abstract

ObjectiveTo assess the prevalence and determinants of food insecurity among people living with HIV (PLWH) in Pune, India and its association with biomarkers known to confer increased risks of morbidity and mortality in this population.DesignCross-sectional analysis assessing food insecurity using the standardized Household Food Insecurity Access Scale. Participants were dichotomized into two groups: food insecure and food secure. Logistic regression models were used to assess associations between socio-economic, demographic, clinical, biochemical factors and food insecurity.SettingAntiretroviral therapy (ART) centre of Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals (BJGMC-SGH), Pune, a large publicly funded tertiary and teaching hospital in western India.ParticpantsAdult (≥18 years) PLWH attending the ART centre between September 2015 and May 2016 who had received ART for either ≤7d (ART-naïve) or ≥1 year (ART-experienced).ResultsFood insecurity was reported by 40 % of 483 participants. Independent risk factors (adjusted OR; 95 % CI) included monthly family income <INR 5000 (∼70 USD; 13·2; CI 5·4, 32·2) and consuming ≥4 non-vegetarian meals per week (4·7; 1·9, 11·9). High-sensitivity C-reactive protein (hs-CRP) ≥0·33 mg/dl (1·6; 1·04, 2·6) and d-dimer levels 0·19-0·31 μg/ml (1·6; 1·01, 2·6) and ≥0·32 μg/ml (1·9; 1·2, 3·2) were also associated with food insecurity.ConclusionsMore than a third of the study participants were food insecure. Furthermore, higher hs-CRP and d-dimer levels were associated with food insecurity. Prospective studies are required to understand the relationship between food insecurity, hs-CRP and d-dimer better.

Original languageEnglish (US)
JournalPublic health nutrition
DOIs
StatePublished - Jan 1 2019

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Food Supply
C-Reactive Protein
India
HIV
Food
Logistic Models
International Normalized Ratio
Tertiary Care Centers
Teaching Hospitals
General Hospitals
Meals
Biomarkers
Economics
Demography
Prospective Studies
Morbidity
Mortality
Population

Keywords

  • d-Dimer
  • Food insecurity
  • High-sensitivity C-reactive protein
  • HIV
  • India

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health

Cite this

Elevated highly sensitive C-reactive protein and d-dimer levels are associated with food insecurity among people living with HIV in Pune, India. / Patil, Sandesh; Kadam, Dileep; Mehtani, Nicky; Sangle, Shashikala; Marbaniang, Ivan; Kulkarni, Vandana; Shere, Dhananjay; Deshpande, Prasad; Dhumal, Gauri; Suryavanshi, Nishi; Gupte, Nikhil; Bollinger, Robert C; Deluca, Andrea; Nevrekar, Neetal; Menon, Pramila; Kawade, Rama; Patil, Mansi; Gupta, Amita; Mave, Vidya.

In: Public health nutrition, 01.01.2019.

Research output: Contribution to journalArticle

Patil, Sandesh ; Kadam, Dileep ; Mehtani, Nicky ; Sangle, Shashikala ; Marbaniang, Ivan ; Kulkarni, Vandana ; Shere, Dhananjay ; Deshpande, Prasad ; Dhumal, Gauri ; Suryavanshi, Nishi ; Gupte, Nikhil ; Bollinger, Robert C ; Deluca, Andrea ; Nevrekar, Neetal ; Menon, Pramila ; Kawade, Rama ; Patil, Mansi ; Gupta, Amita ; Mave, Vidya. / Elevated highly sensitive C-reactive protein and d-dimer levels are associated with food insecurity among people living with HIV in Pune, India. In: Public health nutrition. 2019.
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abstract = "ObjectiveTo assess the prevalence and determinants of food insecurity among people living with HIV (PLWH) in Pune, India and its association with biomarkers known to confer increased risks of morbidity and mortality in this population.DesignCross-sectional analysis assessing food insecurity using the standardized Household Food Insecurity Access Scale. Participants were dichotomized into two groups: food insecure and food secure. Logistic regression models were used to assess associations between socio-economic, demographic, clinical, biochemical factors and food insecurity.SettingAntiretroviral therapy (ART) centre of Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals (BJGMC-SGH), Pune, a large publicly funded tertiary and teaching hospital in western India.ParticpantsAdult (≥18 years) PLWH attending the ART centre between September 2015 and May 2016 who had received ART for either ≤7d (ART-na{\"i}ve) or ≥1 year (ART-experienced).ResultsFood insecurity was reported by 40 {\%} of 483 participants. Independent risk factors (adjusted OR; 95 {\%} CI) included monthly family income <INR 5000 (∼70 USD; 13·2; CI 5·4, 32·2) and consuming ≥4 non-vegetarian meals per week (4·7; 1·9, 11·9). High-sensitivity C-reactive protein (hs-CRP) ≥0·33 mg/dl (1·6; 1·04, 2·6) and d-dimer levels 0·19-0·31 μg/ml (1·6; 1·01, 2·6) and ≥0·32 μg/ml (1·9; 1·2, 3·2) were also associated with food insecurity.ConclusionsMore than a third of the study participants were food insecure. Furthermore, higher hs-CRP and d-dimer levels were associated with food insecurity. Prospective studies are required to understand the relationship between food insecurity, hs-CRP and d-dimer better.",
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T1 - Elevated highly sensitive C-reactive protein and d-dimer levels are associated with food insecurity among people living with HIV in Pune, India

AU - Patil, Sandesh

AU - Kadam, Dileep

AU - Mehtani, Nicky

AU - Sangle, Shashikala

AU - Marbaniang, Ivan

AU - Kulkarni, Vandana

AU - Shere, Dhananjay

AU - Deshpande, Prasad

AU - Dhumal, Gauri

AU - Suryavanshi, Nishi

AU - Gupte, Nikhil

AU - Bollinger, Robert C

AU - Deluca, Andrea

AU - Nevrekar, Neetal

AU - Menon, Pramila

AU - Kawade, Rama

AU - Patil, Mansi

AU - Gupta, Amita

AU - Mave, Vidya

PY - 2019/1/1

Y1 - 2019/1/1

N2 - ObjectiveTo assess the prevalence and determinants of food insecurity among people living with HIV (PLWH) in Pune, India and its association with biomarkers known to confer increased risks of morbidity and mortality in this population.DesignCross-sectional analysis assessing food insecurity using the standardized Household Food Insecurity Access Scale. Participants were dichotomized into two groups: food insecure and food secure. Logistic regression models were used to assess associations between socio-economic, demographic, clinical, biochemical factors and food insecurity.SettingAntiretroviral therapy (ART) centre of Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals (BJGMC-SGH), Pune, a large publicly funded tertiary and teaching hospital in western India.ParticpantsAdult (≥18 years) PLWH attending the ART centre between September 2015 and May 2016 who had received ART for either ≤7d (ART-naïve) or ≥1 year (ART-experienced).ResultsFood insecurity was reported by 40 % of 483 participants. Independent risk factors (adjusted OR; 95 % CI) included monthly family income <INR 5000 (∼70 USD; 13·2; CI 5·4, 32·2) and consuming ≥4 non-vegetarian meals per week (4·7; 1·9, 11·9). High-sensitivity C-reactive protein (hs-CRP) ≥0·33 mg/dl (1·6; 1·04, 2·6) and d-dimer levels 0·19-0·31 μg/ml (1·6; 1·01, 2·6) and ≥0·32 μg/ml (1·9; 1·2, 3·2) were also associated with food insecurity.ConclusionsMore than a third of the study participants were food insecure. Furthermore, higher hs-CRP and d-dimer levels were associated with food insecurity. Prospective studies are required to understand the relationship between food insecurity, hs-CRP and d-dimer better.

AB - ObjectiveTo assess the prevalence and determinants of food insecurity among people living with HIV (PLWH) in Pune, India and its association with biomarkers known to confer increased risks of morbidity and mortality in this population.DesignCross-sectional analysis assessing food insecurity using the standardized Household Food Insecurity Access Scale. Participants were dichotomized into two groups: food insecure and food secure. Logistic regression models were used to assess associations between socio-economic, demographic, clinical, biochemical factors and food insecurity.SettingAntiretroviral therapy (ART) centre of Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals (BJGMC-SGH), Pune, a large publicly funded tertiary and teaching hospital in western India.ParticpantsAdult (≥18 years) PLWH attending the ART centre between September 2015 and May 2016 who had received ART for either ≤7d (ART-naïve) or ≥1 year (ART-experienced).ResultsFood insecurity was reported by 40 % of 483 participants. Independent risk factors (adjusted OR; 95 % CI) included monthly family income <INR 5000 (∼70 USD; 13·2; CI 5·4, 32·2) and consuming ≥4 non-vegetarian meals per week (4·7; 1·9, 11·9). High-sensitivity C-reactive protein (hs-CRP) ≥0·33 mg/dl (1·6; 1·04, 2·6) and d-dimer levels 0·19-0·31 μg/ml (1·6; 1·01, 2·6) and ≥0·32 μg/ml (1·9; 1·2, 3·2) were also associated with food insecurity.ConclusionsMore than a third of the study participants were food insecure. Furthermore, higher hs-CRP and d-dimer levels were associated with food insecurity. Prospective studies are required to understand the relationship between food insecurity, hs-CRP and d-dimer better.

KW - d-Dimer

KW - Food insecurity

KW - High-sensitivity C-reactive protein

KW - HIV

KW - India

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