Elevated Epstein-Barr virus seroreactivity among unaffected members of families with nasopharyngeal carcinoma

Hai De Qin, Wei Hua Jia, Lin Lin Zhang, Na Liu, Xin Xi Zhou, Ming Hsi Wang, Qi Sheng Feng, Li Zhen Chen, Ying Zhang, Timothy J. Jorgensen, Yi Xin Zeng, Yin Yao Shugart

Research output: Contribution to journalArticle

Abstract

Serum antibodies to Epstein-Barr virus (EBV) antigens can be used to predict the risk of nasopharyngeal carcinoma (NPC). To investigate whether EBV seropositivity rates were higher among healthy family members from multiplex and sporadic families with NPC (i.e., families with multiple or single cases) compared to the general population, a study was conducted on 2,665 unaffected individuals from 140 multiplex and 413 sporadic families. The titers of the IgA antibody to the EBV capsid antigen (VCA-IgA) were compared to those of 904 controls from the general population. The VCA-IgA titer was correlated among sibling pairs to a high significance in both family types (P

Original languageEnglish (US)
Pages (from-to)1792-1798
Number of pages7
JournalJournal of Medical Virology
Volume83
Issue number10
DOIs
Publication statusPublished - Oct 2011
Externally publishedYes

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Keywords

  • Epstein-Barr virus
  • Familial correlation
  • Multiplex and sporadic families
  • Nasopharyngeal carcinoma
  • Seroreactivity

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Qin, H. D., Jia, W. H., Zhang, L. L., Liu, N., Zhou, X. X., Wang, M. H., ... Shugart, Y. Y. (2011). Elevated Epstein-Barr virus seroreactivity among unaffected members of families with nasopharyngeal carcinoma. Journal of Medical Virology, 83(10), 1792-1798. https://doi.org/10.1002/jmv.22121