Elevated dynorphin in the hippocampal formation of aged rats: Relation to cognitive impairment on a spatial learning task

H. K. Jiang, V. Owyang, J. S. Hong, Michela Gallagher

Research output: Contribution to journalArticle

Abstract

Radioimmunoassay revealed increased dynorphin A(1-8)-like immunoreactivity [dynA(1-8)LI] in the aged rat brain. Among a number of brain regions examined, an age-related dynA(1-8)LI elevation was found only in the hippocampal formation and frontal cortex. Moreover, the increase in dynA(1-8)LI in the aged hippocampus was associated with a decline in spatial learning ability: dynA(1-8)LI distinghuished aged rats that were behaviorally impaired from aged cohorts that learned the spatial taks as rapidly as younger animals. Northern blot hybridization using a 32P-labeled complementary RNA probe encoding rat prodynorphin indicated that the abundance of prodynorphin mRNA was also significantly increased in the hippocampal formation of aged rats with identified spatial learning impairments.

Original languageEnglish (US)
Pages (from-to)2948-2951
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume86
Issue number8
StatePublished - 1989
Externally publishedYes

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Dynorphins
Hippocampus
dynorphin (1-8)
RNA Probes
Complementary RNA
Brain
Frontal Lobe
Northern Blotting
Radioimmunoassay
Messenger RNA
Cognitive Dysfunction
Spatial Learning
preproenkephalin

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

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title = "Elevated dynorphin in the hippocampal formation of aged rats: Relation to cognitive impairment on a spatial learning task",
abstract = "Radioimmunoassay revealed increased dynorphin A(1-8)-like immunoreactivity [dynA(1-8)LI] in the aged rat brain. Among a number of brain regions examined, an age-related dynA(1-8)LI elevation was found only in the hippocampal formation and frontal cortex. Moreover, the increase in dynA(1-8)LI in the aged hippocampus was associated with a decline in spatial learning ability: dynA(1-8)LI distinghuished aged rats that were behaviorally impaired from aged cohorts that learned the spatial taks as rapidly as younger animals. Northern blot hybridization using a 32P-labeled complementary RNA probe encoding rat prodynorphin indicated that the abundance of prodynorphin mRNA was also significantly increased in the hippocampal formation of aged rats with identified spatial learning impairments.",
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T1 - Elevated dynorphin in the hippocampal formation of aged rats

T2 - Relation to cognitive impairment on a spatial learning task

AU - Jiang, H. K.

AU - Owyang, V.

AU - Hong, J. S.

AU - Gallagher, Michela

PY - 1989

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