Elevated dynorphin in the hippocampal formation of aged rats: Relation to cognitive impairment on a spatial learning task

H. K. Jiang, V. Owyang, J. S. Hong, M. Gallagher

Research output: Contribution to journalArticle

Abstract

Radioimmunoassay revealed increased dynorphin A(1-8)-like immunoreactivity [dynA(1-8)LI] in the aged rat brain. Among a number of brain regions examined, an age-related dynA(1-8)LI elevation was found only in the hippocampal formation and frontal cortex. Moreover, the increase in dynA(1-8)LI in the aged hippocampus was associated with a decline in spatial learning ability: dynA(1-8)LI distinghuished aged rats that were behaviorally impaired from aged cohorts that learned the spatial taks as rapidly as younger animals. Northern blot hybridization using a 32P-labeled complementary RNA probe encoding rat prodynorphin indicated that the abundance of prodynorphin mRNA was also significantly increased in the hippocampal formation of aged rats with identified spatial learning impairments.

Original languageEnglish (US)
Pages (from-to)2948-2951
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume86
Issue number8
DOIs
StatePublished - 1989
Externally publishedYes

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