Abstract
Radioimmunoassay revealed increased dynorphin A(1-8)-like immunoreactivity [dynA(1-8)LI] in the aged rat brain. Among a number of brain regions examined, an age-related dynA(1-8)LI elevation was found only in the hippocampal formation and frontal cortex. Moreover, the increase in dynA(1-8)LI in the aged hippocampus was associated with a decline in spatial learning ability: dynA(1-8)LI distinghuished aged rats that were behaviorally impaired from aged cohorts that learned the spatial taks as rapidly as younger animals. Northern blot hybridization using a 32P-labeled complementary RNA probe encoding rat prodynorphin indicated that the abundance of prodynorphin mRNA was also significantly increased in the hippocampal formation of aged rats with identified spatial learning impairments.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2948-2951 |
| Number of pages | 4 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 86 |
| Issue number | 8 |
| State | Published - 1989 |
| Externally published | Yes |
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ASJC Scopus subject areas
- General
- Genetics
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Elevated dynorphin in the hippocampal formation of aged rats : Relation to cognitive impairment on a spatial learning task. / Jiang, H. K.; Owyang, V.; Hong, J. S.; Gallagher, Michela.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, No. 8, 1989, p. 2948-2951.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Elevated dynorphin in the hippocampal formation of aged rats
T2 - Relation to cognitive impairment on a spatial learning task
AU - Jiang, H. K.
AU - Owyang, V.
AU - Hong, J. S.
AU - Gallagher, Michela
PY - 1989
Y1 - 1989
N2 - Radioimmunoassay revealed increased dynorphin A(1-8)-like immunoreactivity [dynA(1-8)LI] in the aged rat brain. Among a number of brain regions examined, an age-related dynA(1-8)LI elevation was found only in the hippocampal formation and frontal cortex. Moreover, the increase in dynA(1-8)LI in the aged hippocampus was associated with a decline in spatial learning ability: dynA(1-8)LI distinghuished aged rats that were behaviorally impaired from aged cohorts that learned the spatial taks as rapidly as younger animals. Northern blot hybridization using a 32P-labeled complementary RNA probe encoding rat prodynorphin indicated that the abundance of prodynorphin mRNA was also significantly increased in the hippocampal formation of aged rats with identified spatial learning impairments.
AB - Radioimmunoassay revealed increased dynorphin A(1-8)-like immunoreactivity [dynA(1-8)LI] in the aged rat brain. Among a number of brain regions examined, an age-related dynA(1-8)LI elevation was found only in the hippocampal formation and frontal cortex. Moreover, the increase in dynA(1-8)LI in the aged hippocampus was associated with a decline in spatial learning ability: dynA(1-8)LI distinghuished aged rats that were behaviorally impaired from aged cohorts that learned the spatial taks as rapidly as younger animals. Northern blot hybridization using a 32P-labeled complementary RNA probe encoding rat prodynorphin indicated that the abundance of prodynorphin mRNA was also significantly increased in the hippocampal formation of aged rats with identified spatial learning impairments.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024566999&partnerID=8YFLogxK
M3 - Article
C2 - 2565040
AN - SCOPUS:0024566999
VL - 86
SP - 2948
EP - 2951
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 8
ER -