Elevated blood pressure in spontaneously hypertensive rats consuming a high sucrose diet is associated with elevated angiotensin II and is reversed by vanadium

Shang Jin Shi, Harry G. Preuss, Darrell R. Abernethy, Xin Li, S. Taylor Jarrell, Nabil S. Andrawis

Research output: Contribution to journalArticle

Abstract

Objective. To determine the changes in serum angiotensin II (Ang II) and endothelin-1 levels induced by vanadium treatment of sugar-fed rats in order to investigate the relationship between changes in blood pressure and Ang II and endothelin-1 levels. Methods. Male spontaneously hypertensive rats (SHR) were fed starch (control), sucrose, and sucrose plus vanadium compounds at various concentrations. The systolic blood pressure of the rats was estimated by tail-cuff plethysmography. Serum Ang II and endothelin-1 levels were measured by radioimmunoassay. Results. There were increases in systolic blood pressure (by 8%) and in serum Ang II (by 20%) in sucrose-fed SHR compared with control. In sucrose plus vanadium-fed SHR, the lowering of the systolic blood pressure (by 11-16% of the sucrose-fed value) was accompanied by a significant decrease in Ang II levels (by 25-60% of the sucrose-fed value) and an increase in endothelin-1 level (by 61-76% of the sucrose-fed value). Conclusion. That Ang II levels are elevated in sucrose-induced hypertension and decreased after vanadium therapy suggests that the renin-angiotensin system plays a role in the induction of hypertension in this model. On the other hand, the elevation of endothelin-1 levels associated with a decreased systolic blood pressure might be secondary to vanadium stimulation of endothelial cells. The data suggest that endothelin-1 is not involved in sugar-induced elevations of the blood pressure.

Original languageEnglish (US)
Pages (from-to)857-862
Number of pages6
JournalJournal of Hypertension
Volume15
Issue number8
DOIs
StatePublished - 1997
Externally publishedYes

Fingerprint

Vanadium
Inbred SHR Rats
Angiotensin II
Sucrose
Diet
Blood Pressure
Endothelin-1
Vanadium Compounds
Serum
Hypertension
Plethysmography
Renin-Angiotensin System
Starch
Radioimmunoassay
Tail
Endothelial Cells

Keywords

  • Angiotensin II
  • Blood pressure
  • Endothelin-1
  • Spontaneously hypertensive rats
  • Sucrose
  • Vanadium

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology

Cite this

Elevated blood pressure in spontaneously hypertensive rats consuming a high sucrose diet is associated with elevated angiotensin II and is reversed by vanadium. / Shi, Shang Jin; Preuss, Harry G.; Abernethy, Darrell R.; Li, Xin; Jarrell, S. Taylor; Andrawis, Nabil S.

In: Journal of Hypertension, Vol. 15, No. 8, 1997, p. 857-862.

Research output: Contribution to journalArticle

Shi, Shang Jin ; Preuss, Harry G. ; Abernethy, Darrell R. ; Li, Xin ; Jarrell, S. Taylor ; Andrawis, Nabil S. / Elevated blood pressure in spontaneously hypertensive rats consuming a high sucrose diet is associated with elevated angiotensin II and is reversed by vanadium. In: Journal of Hypertension. 1997 ; Vol. 15, No. 8. pp. 857-862.
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abstract = "Objective. To determine the changes in serum angiotensin II (Ang II) and endothelin-1 levels induced by vanadium treatment of sugar-fed rats in order to investigate the relationship between changes in blood pressure and Ang II and endothelin-1 levels. Methods. Male spontaneously hypertensive rats (SHR) were fed starch (control), sucrose, and sucrose plus vanadium compounds at various concentrations. The systolic blood pressure of the rats was estimated by tail-cuff plethysmography. Serum Ang II and endothelin-1 levels were measured by radioimmunoassay. Results. There were increases in systolic blood pressure (by 8{\%}) and in serum Ang II (by 20{\%}) in sucrose-fed SHR compared with control. In sucrose plus vanadium-fed SHR, the lowering of the systolic blood pressure (by 11-16{\%} of the sucrose-fed value) was accompanied by a significant decrease in Ang II levels (by 25-60{\%} of the sucrose-fed value) and an increase in endothelin-1 level (by 61-76{\%} of the sucrose-fed value). Conclusion. That Ang II levels are elevated in sucrose-induced hypertension and decreased after vanadium therapy suggests that the renin-angiotensin system plays a role in the induction of hypertension in this model. On the other hand, the elevation of endothelin-1 levels associated with a decreased systolic blood pressure might be secondary to vanadium stimulation of endothelial cells. The data suggest that endothelin-1 is not involved in sugar-induced elevations of the blood pressure.",
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T1 - Elevated blood pressure in spontaneously hypertensive rats consuming a high sucrose diet is associated with elevated angiotensin II and is reversed by vanadium

AU - Shi, Shang Jin

AU - Preuss, Harry G.

AU - Abernethy, Darrell R.

AU - Li, Xin

AU - Jarrell, S. Taylor

AU - Andrawis, Nabil S.

PY - 1997

Y1 - 1997

N2 - Objective. To determine the changes in serum angiotensin II (Ang II) and endothelin-1 levels induced by vanadium treatment of sugar-fed rats in order to investigate the relationship between changes in blood pressure and Ang II and endothelin-1 levels. Methods. Male spontaneously hypertensive rats (SHR) were fed starch (control), sucrose, and sucrose plus vanadium compounds at various concentrations. The systolic blood pressure of the rats was estimated by tail-cuff plethysmography. Serum Ang II and endothelin-1 levels were measured by radioimmunoassay. Results. There were increases in systolic blood pressure (by 8%) and in serum Ang II (by 20%) in sucrose-fed SHR compared with control. In sucrose plus vanadium-fed SHR, the lowering of the systolic blood pressure (by 11-16% of the sucrose-fed value) was accompanied by a significant decrease in Ang II levels (by 25-60% of the sucrose-fed value) and an increase in endothelin-1 level (by 61-76% of the sucrose-fed value). Conclusion. That Ang II levels are elevated in sucrose-induced hypertension and decreased after vanadium therapy suggests that the renin-angiotensin system plays a role in the induction of hypertension in this model. On the other hand, the elevation of endothelin-1 levels associated with a decreased systolic blood pressure might be secondary to vanadium stimulation of endothelial cells. The data suggest that endothelin-1 is not involved in sugar-induced elevations of the blood pressure.

AB - Objective. To determine the changes in serum angiotensin II (Ang II) and endothelin-1 levels induced by vanadium treatment of sugar-fed rats in order to investigate the relationship between changes in blood pressure and Ang II and endothelin-1 levels. Methods. Male spontaneously hypertensive rats (SHR) were fed starch (control), sucrose, and sucrose plus vanadium compounds at various concentrations. The systolic blood pressure of the rats was estimated by tail-cuff plethysmography. Serum Ang II and endothelin-1 levels were measured by radioimmunoassay. Results. There were increases in systolic blood pressure (by 8%) and in serum Ang II (by 20%) in sucrose-fed SHR compared with control. In sucrose plus vanadium-fed SHR, the lowering of the systolic blood pressure (by 11-16% of the sucrose-fed value) was accompanied by a significant decrease in Ang II levels (by 25-60% of the sucrose-fed value) and an increase in endothelin-1 level (by 61-76% of the sucrose-fed value). Conclusion. That Ang II levels are elevated in sucrose-induced hypertension and decreased after vanadium therapy suggests that the renin-angiotensin system plays a role in the induction of hypertension in this model. On the other hand, the elevation of endothelin-1 levels associated with a decreased systolic blood pressure might be secondary to vanadium stimulation of endothelial cells. The data suggest that endothelin-1 is not involved in sugar-induced elevations of the blood pressure.

KW - Angiotensin II

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