Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease

M. A. Lovell, W. D. Ehmann, M. P. Mattson, W. R. Markesbery

Research output: Contribution to journalArticle

Abstract

4-Hydroxynonenal (4-HNE), an aldehyde by-product of the peroxidation of fatty acids, has been shown to have toxic properties for neurons in culture. In light of increasing evidence that oxidative stress contributes to the neurodegenerative process in Alzheimer's disease (AD) we quantified levels of free and protein-bound 4-HNE in the ventricular fluid from 19 AD subjects and 13 control subjects by high-pressure liquid chromatography and dot-blot immunoassay. Free 4-HNE levels were found to be significantly elevated in the ventricular fluid of AD subjects compared with control subjects (p = 0.0096). These results demonstrate increased lipid peroxidation in AD brain and suggest a role for 4-HNE in the neurodegenerative process.

Original languageEnglish (US)
Pages (from-to)457-461
Number of pages5
JournalNeurobiology of Aging
Volume18
Issue number5
DOIs
StatePublished - Sep 1997
Externally publishedYes

Fingerprint

Alzheimer Disease
Poisons
Immunoassay
Aldehydes
Lipid Peroxidation
Oxidative Stress
Fatty Acids
High Pressure Liquid Chromatography
Neurons
4-hydroxy-2-nonenal
Brain
Proteins

Keywords

  • 4-Hydroxynonenal
  • Alzheimer's disease
  • Lipid peroxidation
  • Oxidative stress
  • Ventricular fluid

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Lovell, M. A., Ehmann, W. D., Mattson, M. P., & Markesbery, W. R. (1997). Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease. Neurobiology of Aging, 18(5), 457-461. https://doi.org/10.1016/S0197-4580(97)00108-5

Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease. / Lovell, M. A.; Ehmann, W. D.; Mattson, M. P.; Markesbery, W. R.

In: Neurobiology of Aging, Vol. 18, No. 5, 09.1997, p. 457-461.

Research output: Contribution to journalArticle

Lovell, MA, Ehmann, WD, Mattson, MP & Markesbery, WR 1997, 'Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease', Neurobiology of Aging, vol. 18, no. 5, pp. 457-461. https://doi.org/10.1016/S0197-4580(97)00108-5
Lovell, M. A. ; Ehmann, W. D. ; Mattson, M. P. ; Markesbery, W. R. / Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease. In: Neurobiology of Aging. 1997 ; Vol. 18, No. 5. pp. 457-461.
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