Electrostatic ligand coatings of nanoparticles enable ligand-specific gene delivery to human primary cells

Jordan J. Green, Eugene Chiu, Elizaveta S. Leshchiner, Julie Shi, Robert Langer, Daniel G. Anderson

Research output: Contribution to journalArticle

Abstract

A general method of coating polymer/DNA nanoparticles was developed. Peptide coated nanoparticles were found to have favorable biophysical characteristics including small particle size, near-neutral ζ potential, and stability in serum. At appropriate formulation conditions including near-neutral charge ratio, the coated nanoparticles enabled effective ligand-specific gene delivery to human primary endothelial cells in serum-containing media. As this nanoparticulate drug delivery system has high efficacy, ligand-based specificity, biodegradability, and low cytotoxicity, it may be potentially useful in several clinical applications.

Original languageEnglish (US)
Pages (from-to)874-879
Number of pages6
JournalNano Letters
Volume7
Issue number4
DOIs
StatePublished - Apr 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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