Abstract
The development of a biodegradable, biocompatible tubular scaffold that mimics the architecture of a vessel's own extracellular matrix was described. The polycaprolactone (PCL) scaffolds were electrospun onto a stainless steel rod rotating at 30 rpm to create closed-end tubes approximately 3 mm in diameter and 30 mm long having a wall thickness of 40 μm. Cultured vascular smooth muscle cells were loaded into the sterilized scaffolds under low serum conditions. The VSMC attachment and migration through the scaffold walls were studied. It was observed that electrospun PCL scaffolds provided an environment upon which human VSMCs attach and migrate.
| Original language | English (US) |
|---|---|
| Title of host publication | Transactions - 7th World Biomaterials Congress |
| Pages | 1677 |
| Number of pages | 1 |
| State | Published - 2004 |
| Externally published | Yes |
| Event | Transactions - 7th World Biomaterials Congress - Sydney, Australia Duration: May 17 2004 → May 21 2004 |
Other
| Other | Transactions - 7th World Biomaterials Congress |
|---|---|
| Country | Australia |
| City | Sydney |
| Period | 5/17/04 → 5/21/04 |
Fingerprint
ASJC Scopus subject areas
- Engineering(all)
Cite this
Electrospun tubular scaffolds for vascular tissue engineering. / Powell, H. M.; Mitra, S.; Kniss, D. A.; Lannutti, J. J.; Flavahan, Nicholas.
Transactions - 7th World Biomaterials Congress. 2004. p. 1677.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Electrospun tubular scaffolds for vascular tissue engineering
AU - Powell, H. M.
AU - Mitra, S.
AU - Kniss, D. A.
AU - Lannutti, J. J.
AU - Flavahan, Nicholas
PY - 2004
Y1 - 2004
N2 - The development of a biodegradable, biocompatible tubular scaffold that mimics the architecture of a vessel's own extracellular matrix was described. The polycaprolactone (PCL) scaffolds were electrospun onto a stainless steel rod rotating at 30 rpm to create closed-end tubes approximately 3 mm in diameter and 30 mm long having a wall thickness of 40 μm. Cultured vascular smooth muscle cells were loaded into the sterilized scaffolds under low serum conditions. The VSMC attachment and migration through the scaffold walls were studied. It was observed that electrospun PCL scaffolds provided an environment upon which human VSMCs attach and migrate.
AB - The development of a biodegradable, biocompatible tubular scaffold that mimics the architecture of a vessel's own extracellular matrix was described. The polycaprolactone (PCL) scaffolds were electrospun onto a stainless steel rod rotating at 30 rpm to create closed-end tubes approximately 3 mm in diameter and 30 mm long having a wall thickness of 40 μm. Cultured vascular smooth muscle cells were loaded into the sterilized scaffolds under low serum conditions. The VSMC attachment and migration through the scaffold walls were studied. It was observed that electrospun PCL scaffolds provided an environment upon which human VSMCs attach and migrate.
UR - http://www.scopus.com/inward/record.url?scp=13844255854&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=13844255854&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:13844255854
SN - 1877040193
SN - 9781877040191
SP - 1677
BT - Transactions - 7th World Biomaterials Congress
ER -