Electrospun tubular scaffolds for vascular tissue engineering

H. M. Powell, S. Mitra, D. A. Kniss, J. J. Lannutti, N. Flavahan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The development of a biodegradable, biocompatible tubular scaffold that mimics the architecture of a vessel's own extracellular matrix was described. The polycaprolactone (PCL) scaffolds were electrospun onto a stainless steel rod rotating at 30 rpm to create closed-end tubes approximately 3 mm in diameter and 30 mm long having a wall thickness of 40 μm. Cultured vascular smooth muscle cells were loaded into the sterilized scaffolds under low serum conditions. The VSMC attachment and migration through the scaffold walls were studied. It was observed that electrospun PCL scaffolds provided an environment upon which human VSMCs attach and migrate.

Original languageEnglish (US)
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
StatePublished - Dec 1 2004
Externally publishedYes
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Publication series

NameTransactions - 7th World Biomaterials Congress

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period5/17/045/21/04

ASJC Scopus subject areas

  • Engineering(all)

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