The development of a biodegradable, biocompatible tubular scaffold that mimics the architecture of a vessel's own extracellular matrix was described. The polycaprolactone (PCL) scaffolds were electrospun onto a stainless steel rod rotating at 30 rpm to create closed-end tubes approximately 3 mm in diameter and 30 mm long having a wall thickness of 40 μm. Cultured vascular smooth muscle cells were loaded into the sterilized scaffolds under low serum conditions. The VSMC attachment and migration through the scaffold walls were studied. It was observed that electrospun PCL scaffolds provided an environment upon which human VSMCs attach and migrate.