Electrophysiology studies in patients undergoing ICD implantation: Findings from the NCDR®

Alan Cheng, Yongfei Wang, Ronald D. Berger, Hugh Calkins, Alfred E. Buxton, Jeptha P. Curtis, Rachel Lampert

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Background: Electrophysiology studies (EPS) have historically played a role in sudden death risk stratification. More recent studies point to the left ventricular ejection fraction (EF) as a guide to implantable cardioverter defibrillators (ICD) implantation. The extent of EPS use in patients undergoing ICD implantation in the current era remains unknown. Methods: Patients undergoing de novo ICD implantation in the ICD Registry between September 2006 and March 2009 who also underwent EPS within 30 days before implant were compared to the remaining cohort to identify clinical characteristics that correlated with EPS performance. Multivariate models were generated using hierarchical logistic regression analysis. Results: EPS were performed in 33,786 of 275,273 patients. Those undergoing EPS were more likely to have had a history of syncope, family history of sudden death, lack of congestive heart failure, narrower QRS intervals, and higher EF. Overall, 63.9% of EPS were performed in patients receiving primary prevention ICDs. Ventricular tachyarrhythmias were induced in 46.1% of primary prevention and 54.2% of secondary prevention ICD recipients. Monomorphic ventricular tachycardia was the most common type of arrhythmia induced in both groups. Complication rates were not higher in those undergoing EPS. Conclusions: EPS were performed predominantly in patients with borderline or less well-defined risk factors for sudden death. Ventricular arrhythmias induced from EPS were not uncommon and may help identify individuals at higher risk for future ICD therapies. Efforts to better define the role of EPS in patients undergoing ICD implantation should be considered. (PACE 2012; 35:912-918)

Original languageEnglish (US)
Pages (from-to)912-918
Number of pages7
JournalPACE - Pacing and Clinical Electrophysiology
Issue number8
StatePublished - Aug 2012


  • ICDs
  • NCDR
  • arrhythmia
  • electrophysiology studies
  • ventricular tachycardia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Electrophysiology studies in patients undergoing ICD implantation: Findings from the NCDR®'. Together they form a unique fingerprint.

Cite this