Electrophysiology in the investigation of acquired retinal disorders

Hendrik P N Scholl, Eberhart Zrenner

Research output: Contribution to journalArticle

Abstract

Electrophysiological research on acquired retinal disorders, both common and rare, is reviewed. Age is a major factor influencing electroretinogram (ERG) and electro-oculogram (EOG) findings. Bipolar or Muller cell death in the aging retina could account for much of the amplitude decline that is observed with age. In diabetic retinopathy, the oscillatory potentials can monitor the progression of the disease and indicate neuronal alterations rather than diabetic angiopathy of the retina. Human ERG studies on glaucoma concentrated on ERG measures that are dominated by inner retinal contributions. It has been shown that the pattern ERG can serve as a predictor of ocular hypertension's progression to glaucoma. In retinal disorders caused by endogenous intoxication, such as hepatic retinopathy, or exogenous intoxication from chronic lead exposure, ERG changes give an objective measure of the damage and allow to study the pathophysiological mechanisms that are involved. Inflammations of the choroid and the retina affect the standard ERG when they are diffuse. In central serous chorioretinopathy, functional disturbances can be revealed not only in the photoreceptors but also in the middle and inner retinal layers with the use of focal stimuli. Choroidal melanoma leads to large reductions of the EOG light peak-to-dark trough ratio through its influence on the transepithelial potential of the retinal pigment epithelium (RPE). In cancer-associated retinopathy, both the rod and cone ERGs are reduced. However, selective cone dysfunction has been described. In melanoma-associated retinopathy, the long flash ERG may reveal a specific pathophysiological mechanism, namely the affection of the ON-pathway with preservation of the OFF-pathway. ERG measurements can reveal vitamin A deficiency and are altered in cases with a mutation in the gene for the retinol binding protein in which other organs are not affected. Photochemical damage to the retina from light emission by the operating microscope can be assessed by electrophysiological methods. (C) 2000 by Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)29-47
Number of pages19
JournalSurvey of Ophthalmology
Volume45
Issue number1
DOIs
StatePublished - Jul 15 2000
Externally publishedYes

Fingerprint

Electrophysiology
Retina
Ocular Paraneoplastic Syndromes
Glaucoma
Central Serous Chorioretinopathy
Ependymoglial Cells
Light
Vitamin A Deficiency
Diabetic Angiopathies
Retinol-Binding Proteins
Ocular Hypertension
Vertebrate Photoreceptor Cells
Choroid
Retinal Pigment Epithelium
Diabetic Retinopathy
Disease Progression
Melanoma
Cell Death
Inflammation
Mutation

Keywords

  • Acquired retinal disorders
  • Aging
  • Cancer-associated retinopathy
  • Central serous chorioretinopathy
  • Chorioretinits
  • Choroidal melanoma
  • Diabetic retinopathy
  • Electrooculogram
  • Electrophysiology
  • Electroretinogram
  • Glaucoma
  • Hepatic retinopathy
  • Lead
  • Photochemical damage
  • Retinol binding protein
  • Vitamin A deficiency

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Electrophysiology in the investigation of acquired retinal disorders. / Scholl, Hendrik P N; Zrenner, Eberhart.

In: Survey of Ophthalmology, Vol. 45, No. 1, 15.07.2000, p. 29-47.

Research output: Contribution to journalArticle

Scholl, Hendrik P N ; Zrenner, Eberhart. / Electrophysiology in the investigation of acquired retinal disorders. In: Survey of Ophthalmology. 2000 ; Vol. 45, No. 1. pp. 29-47.
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