Electrophysiological modeling of cardiac ventricular function: From cell to organ

R. L. Winslow, D. F. Scollan, A. Holmes, C. K. Yung, J. Zhang, M. S. Jafri

Research output: Contribution to journalArticlepeer-review

Abstract

Three topics of importance to modeling the integrative function of the heart are reviewed. The first is modeling of the ventricular myocyte. Emphasis is placed on excitation-contraction coupling and intracellular Ca2+ handling, and the interpretation of experimental data regarding interval-force relationships. Second, data on use of diffusion tensor magnetic resonance (DTMR) imaging for measuring the anatomical structure of the cardiac ventricles are presented. A method for the semi-automated reconstruction of the ventricles using a combination of gradient recalled acquisition in the steady state (GRASS) and DTMR images is described. Third, we describe how these anatomically and biophysically based models of the cardiac ventricles can be implemented on parallel computers.

Original languageEnglish (US)
Pages (from-to)119-155
Number of pages37
JournalAnnual Review of Biomedical Engineering
Volume2
Issue number2000
DOIs
StatePublished - 2000

Keywords

  • Calcium
  • Excitation-contraction coupling
  • Ion channels
  • Magnetic resonance
  • Parallel computing

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomedical Engineering

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