Electrophysiological evidence for visuocognitive dysfunction in younger non caucasian patients with Parkinson's disease

L. Sagliocco, F. Bandini, M. Pierantozzi, Z. Mari, A. Tzelepi, C. Ko, J. Gulzar, I. Bodis-Wollner

Research output: Contribution to journalArticle

Abstract

A study of 'primary' (VEPs) and 'cognitive' (ERPs) visual evoked potentials was carried out in a group of non-demented Afro-American Parkinson's disease (PD) patients. Current studies suggest that differences exist in the clinical manifestations of PD in Caucasian and non-Caucasian populations. Two horizontal sinusoidal gratings differing in spatial frequency, i.e., 1 and 4 cycles per degree (cpd), were presented in an 'oddball' paradigm to 17 patients with PD and 17 age-matched control subjects. While the 1 cpd stimulus, is not expected to reveal retinal dopaminergic deficency, but only visuocognitive deficits, the 4cpd may give direct information of both 'retinal' and 'cognitive' visual deficits. We measured the latencies and amplitudes of N70, P100 and P300 components, and derived the 'normalized' measures of P300-N70 latency difference (Central Processing Time-CPT70), the P300-P100 latency difference (CPT100) and the P300 amplitude responses normalized to either N70 and P100 amplitude (Amplitude Ratios AR70 and AR100). Our results do show that cognitive electrophysiological deficits in younger PD patients exist in non-Caucasians, perhaps to an even greater degree than in Caucasians, and confirm that absolute and normalized ERP amplitude and latency abnormalities are a distinguishing feature of younger PD patients from controls. In particular P300 measures are abnormal for 1 cpd pattern. A negative correlation exists between P300 amplitude and the motor score. By comparing the results for 1 and 4cpd stimuli it can be concluded that 'primary' and 'cognitive' visual abnormalities are independently affected in PD, implying that visuo-cognitive abnormalities are not passively determined by retinal dopaminergic deficiency.

Original languageEnglish (US)
Pages (from-to)427-439
Number of pages13
JournalJournal of Neural Transmission
Volume104
Issue number4-5
DOIs
StatePublished - 1997
Externally publishedYes

Fingerprint

Parkinson Disease
P300 Event-Related Potentials
Visual Evoked Potentials
Population

Keywords

  • Age effect
  • Parkinson's disease
  • Population comparison
  • VEP
  • Visual P300
  • Visuo-cognitive decline

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sagliocco, L., Bandini, F., Pierantozzi, M., Mari, Z., Tzelepi, A., Ko, C., ... Bodis-Wollner, I. (1997). Electrophysiological evidence for visuocognitive dysfunction in younger non caucasian patients with Parkinson's disease. Journal of Neural Transmission, 104(4-5), 427-439. https://doi.org/10.1007/BF01277661

Electrophysiological evidence for visuocognitive dysfunction in younger non caucasian patients with Parkinson's disease. / Sagliocco, L.; Bandini, F.; Pierantozzi, M.; Mari, Z.; Tzelepi, A.; Ko, C.; Gulzar, J.; Bodis-Wollner, I.

In: Journal of Neural Transmission, Vol. 104, No. 4-5, 1997, p. 427-439.

Research output: Contribution to journalArticle

Sagliocco, L, Bandini, F, Pierantozzi, M, Mari, Z, Tzelepi, A, Ko, C, Gulzar, J & Bodis-Wollner, I 1997, 'Electrophysiological evidence for visuocognitive dysfunction in younger non caucasian patients with Parkinson's disease', Journal of Neural Transmission, vol. 104, no. 4-5, pp. 427-439. https://doi.org/10.1007/BF01277661
Sagliocco, L. ; Bandini, F. ; Pierantozzi, M. ; Mari, Z. ; Tzelepi, A. ; Ko, C. ; Gulzar, J. ; Bodis-Wollner, I. / Electrophysiological evidence for visuocognitive dysfunction in younger non caucasian patients with Parkinson's disease. In: Journal of Neural Transmission. 1997 ; Vol. 104, No. 4-5. pp. 427-439.
@article{aefb4542da084118a098eb6b462ce7af,
title = "Electrophysiological evidence for visuocognitive dysfunction in younger non caucasian patients with Parkinson's disease",
abstract = "A study of 'primary' (VEPs) and 'cognitive' (ERPs) visual evoked potentials was carried out in a group of non-demented Afro-American Parkinson's disease (PD) patients. Current studies suggest that differences exist in the clinical manifestations of PD in Caucasian and non-Caucasian populations. Two horizontal sinusoidal gratings differing in spatial frequency, i.e., 1 and 4 cycles per degree (cpd), were presented in an 'oddball' paradigm to 17 patients with PD and 17 age-matched control subjects. While the 1 cpd stimulus, is not expected to reveal retinal dopaminergic deficency, but only visuocognitive deficits, the 4cpd may give direct information of both 'retinal' and 'cognitive' visual deficits. We measured the latencies and amplitudes of N70, P100 and P300 components, and derived the 'normalized' measures of P300-N70 latency difference (Central Processing Time-CPT70), the P300-P100 latency difference (CPT100) and the P300 amplitude responses normalized to either N70 and P100 amplitude (Amplitude Ratios AR70 and AR100). Our results do show that cognitive electrophysiological deficits in younger PD patients exist in non-Caucasians, perhaps to an even greater degree than in Caucasians, and confirm that absolute and normalized ERP amplitude and latency abnormalities are a distinguishing feature of younger PD patients from controls. In particular P300 measures are abnormal for 1 cpd pattern. A negative correlation exists between P300 amplitude and the motor score. By comparing the results for 1 and 4cpd stimuli it can be concluded that 'primary' and 'cognitive' visual abnormalities are independently affected in PD, implying that visuo-cognitive abnormalities are not passively determined by retinal dopaminergic deficiency.",
keywords = "Age effect, Parkinson's disease, Population comparison, VEP, Visual P300, Visuo-cognitive decline",
author = "L. Sagliocco and F. Bandini and M. Pierantozzi and Z. Mari and A. Tzelepi and C. Ko and J. Gulzar and I. Bodis-Wollner",
year = "1997",
doi = "10.1007/BF01277661",
language = "English (US)",
volume = "104",
pages = "427--439",
journal = "Journal of Neural Transmission",
issn = "0300-9564",
publisher = "Springer Verlag",
number = "4-5",

}

TY - JOUR

T1 - Electrophysiological evidence for visuocognitive dysfunction in younger non caucasian patients with Parkinson's disease

AU - Sagliocco, L.

AU - Bandini, F.

AU - Pierantozzi, M.

AU - Mari, Z.

AU - Tzelepi, A.

AU - Ko, C.

AU - Gulzar, J.

AU - Bodis-Wollner, I.

PY - 1997

Y1 - 1997

N2 - A study of 'primary' (VEPs) and 'cognitive' (ERPs) visual evoked potentials was carried out in a group of non-demented Afro-American Parkinson's disease (PD) patients. Current studies suggest that differences exist in the clinical manifestations of PD in Caucasian and non-Caucasian populations. Two horizontal sinusoidal gratings differing in spatial frequency, i.e., 1 and 4 cycles per degree (cpd), were presented in an 'oddball' paradigm to 17 patients with PD and 17 age-matched control subjects. While the 1 cpd stimulus, is not expected to reveal retinal dopaminergic deficency, but only visuocognitive deficits, the 4cpd may give direct information of both 'retinal' and 'cognitive' visual deficits. We measured the latencies and amplitudes of N70, P100 and P300 components, and derived the 'normalized' measures of P300-N70 latency difference (Central Processing Time-CPT70), the P300-P100 latency difference (CPT100) and the P300 amplitude responses normalized to either N70 and P100 amplitude (Amplitude Ratios AR70 and AR100). Our results do show that cognitive electrophysiological deficits in younger PD patients exist in non-Caucasians, perhaps to an even greater degree than in Caucasians, and confirm that absolute and normalized ERP amplitude and latency abnormalities are a distinguishing feature of younger PD patients from controls. In particular P300 measures are abnormal for 1 cpd pattern. A negative correlation exists between P300 amplitude and the motor score. By comparing the results for 1 and 4cpd stimuli it can be concluded that 'primary' and 'cognitive' visual abnormalities are independently affected in PD, implying that visuo-cognitive abnormalities are not passively determined by retinal dopaminergic deficiency.

AB - A study of 'primary' (VEPs) and 'cognitive' (ERPs) visual evoked potentials was carried out in a group of non-demented Afro-American Parkinson's disease (PD) patients. Current studies suggest that differences exist in the clinical manifestations of PD in Caucasian and non-Caucasian populations. Two horizontal sinusoidal gratings differing in spatial frequency, i.e., 1 and 4 cycles per degree (cpd), were presented in an 'oddball' paradigm to 17 patients with PD and 17 age-matched control subjects. While the 1 cpd stimulus, is not expected to reveal retinal dopaminergic deficency, but only visuocognitive deficits, the 4cpd may give direct information of both 'retinal' and 'cognitive' visual deficits. We measured the latencies and amplitudes of N70, P100 and P300 components, and derived the 'normalized' measures of P300-N70 latency difference (Central Processing Time-CPT70), the P300-P100 latency difference (CPT100) and the P300 amplitude responses normalized to either N70 and P100 amplitude (Amplitude Ratios AR70 and AR100). Our results do show that cognitive electrophysiological deficits in younger PD patients exist in non-Caucasians, perhaps to an even greater degree than in Caucasians, and confirm that absolute and normalized ERP amplitude and latency abnormalities are a distinguishing feature of younger PD patients from controls. In particular P300 measures are abnormal for 1 cpd pattern. A negative correlation exists between P300 amplitude and the motor score. By comparing the results for 1 and 4cpd stimuli it can be concluded that 'primary' and 'cognitive' visual abnormalities are independently affected in PD, implying that visuo-cognitive abnormalities are not passively determined by retinal dopaminergic deficiency.

KW - Age effect

KW - Parkinson's disease

KW - Population comparison

KW - VEP

KW - Visual P300

KW - Visuo-cognitive decline

UR - http://www.scopus.com/inward/record.url?scp=0030874573&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030874573&partnerID=8YFLogxK

U2 - 10.1007/BF01277661

DO - 10.1007/BF01277661

M3 - Article

VL - 104

SP - 427

EP - 439

JO - Journal of Neural Transmission

JF - Journal of Neural Transmission

SN - 0300-9564

IS - 4-5

ER -