Electrophysiological and cerebrovascular effects of the α-secretase-derived form of amyloid precursor protein in young and middle-aged rats

Manuel Sánchez-Alavez, Sic L. Chan, Mark P. Mattson, José R. Criado

Research output: Contribution to journalArticle

Abstract

Cleavage of the β-amyloid precursor protein (APP) by α-secretase releases a secreted form of APP (sAPP) from cells. sAPP is released from neurons in an activity-dependent manner and is believed to play roles in synaptic plasticity and neuroprotection. We determined whether sAPP modulates electrophysiological and cerebrovascular processes in vivo. The effects of recombinant sAPP, applied by intracerebroventricular infusion, on hippocampal and cortical electroencephalographic (EEG) activity and hippocampal blood flow in young adult and middle-aged Long-Evans rats were measured. sAPP increased the power spectrum density of low frequency EEG bands in the hippocampus and cortex of middle-aged rats without affecting hippocampal blood flow. The neurophysiological effects of sAPP were observed in middle-aged, but not in young rats. The results of this study indicate that hippocampal and cortical electrophysiological processes are sensitive to sAPP, whereas the cerebral vasculature may not be regulated by sAPP. The age-dependent change in the sensitivity of neuronal activity to sAPP suggests the possibility of an important role for this APP product in brain functioning in mid life.

Original languageEnglish (US)
Pages (from-to)112-117
Number of pages6
JournalBrain Research
Volume1131
Issue number1
DOIs
StatePublished - Feb 2 2007
Externally publishedYes

Fingerprint

Electrophysiological Phenomena
Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor
Intraventricular Infusions
Long Evans Rats
Neuronal Plasticity
Young Adult
Hippocampus
Neurons
Brain

Keywords

  • Aging
  • Alzheimer's disease
  • Blood flow
  • EEG
  • Hippocampus
  • sAPP

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

Cite this

Electrophysiological and cerebrovascular effects of the α-secretase-derived form of amyloid precursor protein in young and middle-aged rats. / Sánchez-Alavez, Manuel; Chan, Sic L.; Mattson, Mark P.; Criado, José R.

In: Brain Research, Vol. 1131, No. 1, 02.02.2007, p. 112-117.

Research output: Contribution to journalArticle

Sánchez-Alavez, Manuel ; Chan, Sic L. ; Mattson, Mark P. ; Criado, José R. / Electrophysiological and cerebrovascular effects of the α-secretase-derived form of amyloid precursor protein in young and middle-aged rats. In: Brain Research. 2007 ; Vol. 1131, No. 1. pp. 112-117.
@article{5976503fe4594ca79363b9734958c8d2,
title = "Electrophysiological and cerebrovascular effects of the α-secretase-derived form of amyloid precursor protein in young and middle-aged rats",
abstract = "Cleavage of the β-amyloid precursor protein (APP) by α-secretase releases a secreted form of APP (sAPP) from cells. sAPP is released from neurons in an activity-dependent manner and is believed to play roles in synaptic plasticity and neuroprotection. We determined whether sAPP modulates electrophysiological and cerebrovascular processes in vivo. The effects of recombinant sAPP, applied by intracerebroventricular infusion, on hippocampal and cortical electroencephalographic (EEG) activity and hippocampal blood flow in young adult and middle-aged Long-Evans rats were measured. sAPP increased the power spectrum density of low frequency EEG bands in the hippocampus and cortex of middle-aged rats without affecting hippocampal blood flow. The neurophysiological effects of sAPP were observed in middle-aged, but not in young rats. The results of this study indicate that hippocampal and cortical electrophysiological processes are sensitive to sAPP, whereas the cerebral vasculature may not be regulated by sAPP. The age-dependent change in the sensitivity of neuronal activity to sAPP suggests the possibility of an important role for this APP product in brain functioning in mid life.",
keywords = "Aging, Alzheimer's disease, Blood flow, EEG, Hippocampus, sAPP",
author = "Manuel S{\'a}nchez-Alavez and Chan, {Sic L.} and Mattson, {Mark P.} and Criado, {Jos{\'e} R.}",
year = "2007",
month = "2",
day = "2",
doi = "10.1016/j.brainres.2006.10.074",
language = "English (US)",
volume = "1131",
pages = "112--117",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Electrophysiological and cerebrovascular effects of the α-secretase-derived form of amyloid precursor protein in young and middle-aged rats

AU - Sánchez-Alavez, Manuel

AU - Chan, Sic L.

AU - Mattson, Mark P.

AU - Criado, José R.

PY - 2007/2/2

Y1 - 2007/2/2

N2 - Cleavage of the β-amyloid precursor protein (APP) by α-secretase releases a secreted form of APP (sAPP) from cells. sAPP is released from neurons in an activity-dependent manner and is believed to play roles in synaptic plasticity and neuroprotection. We determined whether sAPP modulates electrophysiological and cerebrovascular processes in vivo. The effects of recombinant sAPP, applied by intracerebroventricular infusion, on hippocampal and cortical electroencephalographic (EEG) activity and hippocampal blood flow in young adult and middle-aged Long-Evans rats were measured. sAPP increased the power spectrum density of low frequency EEG bands in the hippocampus and cortex of middle-aged rats without affecting hippocampal blood flow. The neurophysiological effects of sAPP were observed in middle-aged, but not in young rats. The results of this study indicate that hippocampal and cortical electrophysiological processes are sensitive to sAPP, whereas the cerebral vasculature may not be regulated by sAPP. The age-dependent change in the sensitivity of neuronal activity to sAPP suggests the possibility of an important role for this APP product in brain functioning in mid life.

AB - Cleavage of the β-amyloid precursor protein (APP) by α-secretase releases a secreted form of APP (sAPP) from cells. sAPP is released from neurons in an activity-dependent manner and is believed to play roles in synaptic plasticity and neuroprotection. We determined whether sAPP modulates electrophysiological and cerebrovascular processes in vivo. The effects of recombinant sAPP, applied by intracerebroventricular infusion, on hippocampal and cortical electroencephalographic (EEG) activity and hippocampal blood flow in young adult and middle-aged Long-Evans rats were measured. sAPP increased the power spectrum density of low frequency EEG bands in the hippocampus and cortex of middle-aged rats without affecting hippocampal blood flow. The neurophysiological effects of sAPP were observed in middle-aged, but not in young rats. The results of this study indicate that hippocampal and cortical electrophysiological processes are sensitive to sAPP, whereas the cerebral vasculature may not be regulated by sAPP. The age-dependent change in the sensitivity of neuronal activity to sAPP suggests the possibility of an important role for this APP product in brain functioning in mid life.

KW - Aging

KW - Alzheimer's disease

KW - Blood flow

KW - EEG

KW - Hippocampus

KW - sAPP

UR - http://www.scopus.com/inward/record.url?scp=33846019298&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846019298&partnerID=8YFLogxK

U2 - 10.1016/j.brainres.2006.10.074

DO - 10.1016/j.brainres.2006.10.074

M3 - Article

C2 - 17157827

AN - SCOPUS:33846019298

VL - 1131

SP - 112

EP - 117

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -