Electrophysiologic models of heart cells and cell networks: Enabling a better understanding of arrhythmias and heart disease

Nitish V. Thakor, Jose M. Ferrero, Javier Saiz, Boris I. Gramatikov, Jose M. Ferrero

Research output: Contribution to journalReview article


The availability of various experimental techniques to study cardiac cell electrophysiological properties has enabled the formulation of mathematical models of the electrical behavior of excitable cells. These models have been used extensively in cardiac electrophysiology because of their ability to simulate in precise detail the electrical events that take place across the cell membrane. They provide a desirable alternative for exploring the basic electrophysiological mechanisms in normal and abnormal cells. The basic principles of action potential modeling are discussed and the development of cellular models of normal and diseased cells is reviewed.

Original languageEnglish (US)
Pages (from-to)73-83
Number of pages11
JournalIEEE Engineering in Medicine and Biology Magazine
Issue number5
StatePublished - Sep 1 1998


ASJC Scopus subject areas

  • Biomedical Engineering

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