Human embryonic, fetal, and adult globin chains (ζ, ε, Aγ, Gγ, β, α) can be separated by electrophoresis on Triton Acid urea gels. K562, a human leukemia cell line, was induced with hemin, labelled with [3H]-leucine, and globin synthesis analyzed. All globins except β were produced. ε > ζ; Gγ:Aγ=70:30; non-α:α=>2:1. Thus, hemin-induced K562 synthesized embryonic and fetal globin chains, and had globin synthetic imbalance, with "α-thalassemia.".
|Original language||English (US)|
|Number of pages||6|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Jun 16 1980|
ASJC Scopus subject areas
- Molecular Biology