A new method for determining the charge on carrier‐free 99mTc‐labeled complexes is described. This method and mixed‐ligand experiments were used to determine if the charge on the technetium 99m complex of N‐(2,6‐dimethylphenylcarbamoylmethyl)iminodiacetic acid (I) is ‐1 and if the ligand to technetium ratio in the complex is 2:1. The preparation of an iodinated analog (II) of I and its 99mTc‐labeled complex is described, as is the biodistribution of the 99mTc‐labeled complex in mice. The syntheses of the 51Cr(III)‐ and 57Co(III)‐labeled complexes also are described. The net biliary excretion in mice of both the 99mTc‐ and 51Cr‐labeled complexes of II was significantly greater than that of the 99mTc‐labeled complex of I.
- Complexes—technetium 99m with iminodiacetic acid derivatives, electrophoretic determination of charge on carrier‐free c‐labeled complexes, evaluation of net biliary excretion
- N‐(2,6‐Dimethylphenylcarbamoylmethyl)iminodiacetic acid—complexation with technetium 99m, electrophoretic determination of charge on carrier‐free Tc‐labeled complexes, synthesis and evaluation of net biliary excretion
- Radiopharmaceuticals—Tc‐labeled iminodiacetic acid derivatives, electrophoretic determination of charge on carrier‐free Tc‐labeled complexes, synthesis, evaluation of net biliary excretion
ASJC Scopus subject areas
- Pharmaceutical Science