@article{adc0fa7078404ebb8851a3b9fa566a2e,
title = "Electron microscopic study of human papilledema",
abstract = "Papilledema associated with neoplastic invasion of the orbit in the optic disks of two patients was found and examined by light and electron microscopy. Pathologic changes in the optic nerve head and nerve included axonal degeneration and mild interstitial edema. Axonal swelling appeared to be the major factor in the overall increase in tissue volume of the optic nerve head. Vascular and perivascular glial alterations were nonspecific.",
author = "Tso, {Mark O.M.} and Fine, {Ben S.}",
note = "Funding Information: Visual acuity was R.E.: 6/9 (20/30), and L.E.: 6/5 (20/15). Pupils were equally reactive to light. The anterior segment of the right eye was normal. The optic disk of the right eye showed papilledema most marked in the superior and inferior poles. The retinal veins were congested, but no hemorrhages were reported. Intraocular pressure and outflow facility were within normal limits. There was en- From the Registry of Ophthalmic Pathology, Armed Forces Institute of Pathology, and the Department of Ophthalmology, the George Washington University Medical Center, Washington, D.C. This study was supported in part by National Institutes of Health research grant EY-01163 and ΕΥ-00133, and by training grant EY-00032, National Eye Institute, Public Health Service.",
year = "1976",
month = sep,
doi = "10.1016/0002-9394(76)90490-6",
language = "English (US)",
volume = "82",
pages = "424--434",
journal = "American journal of ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "3",
}