Electroencephalographic features of convulsive epilepsy in Africa: A multicentre study of prevalence, pattern and associated factors

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Abstract

Objective: We investigated the prevalence and pattern of electroencephalographic (EEG) features of epilepsy and the associated factors in Africans with active convulsive epilepsy (ACE). Methods: We characterized electroencephalographic features and determined associated factors in a sample of people with ACE in five African sites. Mixed-effects modified Poisson regression model was used to determine factors associated with abnormal EEGs. Results: Recordings were performed on 1426 people of whom 751 (53%) had abnormal EEGs, being an adjusted prevalence of 2.7 (95% confidence interval (95% CI), 2.5-2.9) per 1000. 52% of the abnormal EEG had focal features (75% with temporal lobe involvement). The frequency and pattern of changes differed with site. Abnormal EEGs were associated with adverse perinatal events (risk ratio (RR) = 1.19 (95% CI, 1.07-1.33)), cognitive impairments (RR = 1.50 (95% CI, 1.30-1.73)), use of anti-epileptic drugs (RR = 1.25 (95% CI, 1.05-1.49)), focal seizures (RR = 1.09 (95% CI, 1.00-1.19)) and seizure frequency (RR = 1.18 (95% CI, 1.10-1.26) for daily seizures; RR = 1.22 (95% CI, 1.10-1.35) for weekly seizures and RR = 1.15 (95% CI, 1.03-1.28) for monthly seizures)). Conclusions: EEG abnormalities are common in Africans with epilepsy and are associated with preventable risk factors. Significance: EEG is helpful in identifying focal epilepsy in Africa, where timing of focal aetiologies is problematic and there is a lack of neuroimaging services.

Original languageEnglish (US)
Pages (from-to)1099-1107
Number of pages9
JournalClinical Neurophysiology
Volume127
Issue number2
DOIs
StatePublished - Feb 1 2016

Keywords

  • Active convulsive epilepsy
  • Africa
  • Electroencephalographic features
  • Risk factors

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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