Electrodeposition of hydroxyapatite on a metallic 3D-woven bioscaffold

Ju Xue, Ashley Farris, Yunfei Wang, Weiyan Yeh, Cristina Romany, James K. Guest, Warren L. Grayson, Anthony S. Hall, Timothy P. Weihs

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


In this study, we demonstrate that a uniformcoating of hydroxyapatite (HAp, Ca10(PO4)6(OH)2) can be electrochemically deposited onto metallic 3D-woven bone scaffolds to enhance their bioactivity. TheHAp coatingswere deposited ontometallic scaffolds using an electrolyte containing Ca(NO3)2.4H2O, NH4H2PO4, and NaNO3. The deposition potential was varied tomaximize the uniformity and adhesion of the coating. Using X-ray diffraction (XRD), Raman spectroscopy, and energy-dispersive spectroscopy (EDS), we found crystallized HAp on the 3D-woven lattice under all deposition potentials, while the-1.5 Vmercury sulfate reference electrode potential provided the best local uniformitywith a satisfactory deposition rate. The coatings generated under this optimized condition were approximately 5 μm thick and uniform throughout the internal and external sections of the woven lattice. We seeded and cultured both coated and uncoated scaffolds with human adipose-derived stromal/stem cells (ASCs) for 12 h and 4 days. We observed that the HAp coating increased the initial cell seeding efficiency by approximately 20%. Furthermore, after 4 days of culture, ASCs cultured on HAp-coated stainless-steel scaffolds increased by 32% compared to only 17% on the uncoated scaffold. Together, these results suggest that the HAp coating improves cellular adhesion.

Original languageEnglish (US)
Article number715
Issue number8
StatePublished - 2020


  • 3D-woven lattice
  • Bioscaffolds
  • Bone engineering
  • Electrodeposition
  • Hydroxyapatite

ASJC Scopus subject areas

  • Surfaces and Interfaces
  • Surfaces, Coatings and Films
  • Materials Chemistry


Dive into the research topics of 'Electrodeposition of hydroxyapatite on a metallic 3D-woven bioscaffold'. Together they form a unique fingerprint.

Cite this