Electrocorticographic decoding of ipsilateral reach in the setting of contralateral arm weakness from a cortical lesion

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Brain machine interfaces have the potential for restoring motor function not only in patients with amputations or lesions of efferent pathways in the spinal cord and peripheral nerves, but also patients with acquired brain lesions such as strokes and tumors. In these patients the most efficient components of cortical motor systems are not available for BMI control. Here we had the opportunity to investigate the possibility of utilizing subdural electrocorticographic (ECoG) signals to control natural reaching movements under these circumstances. In a subject with a left arm monoparesis following resection of a recurrent glioma, we found that ECoG signals recorded in remaining cortex were sufficient for decoding kinematics of natural reach movements of the nonparetic arm, ipsilateral to the ECoG recordings. The relationship between the subject's ECoG signals and reach trajectory in three dimensions, two of which were highly correlated, was captured with a computationally simple linear model (mean Pearson's r in depth dimension= 0.68, in height= 0.73, in lateral= 0.24). These results were attained with only a small subset of 7 temporal/spectral neural signal features. The small subset of neural features necessary to attain high decoding results show promise for a restorative BMI controlled solely by ipsilateral ECoG signals.

Original languageEnglish (US)
Title of host publication2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012
Pages4104-4107
Number of pages4
DOIs
StatePublished - Dec 14 2012
Event34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012 - San Diego, CA, United States
Duration: Aug 28 2012Sep 1 2012

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Other

Other34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012
CountryUnited States
CitySan Diego, CA
Period8/28/129/1/12

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ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Hotson, G., Fifer, M. S., Acharya, S., Anderson, W. S., Thakor, N. V., & Crone, N. E. (2012). Electrocorticographic decoding of ipsilateral reach in the setting of contralateral arm weakness from a cortical lesion. In 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012 (pp. 4104-4107). [6346869] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2012.6346869