Electrochemical preparation and EPR studies of lithium phthalocyanine. 3. Measurements of oxygen concentration in tissues and biochemical reactions

Govindasamy Ilangovan, Haiquan Li, Jay L. Zweier, Periannan Kuppusamy

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Abstract

A systematic investigation of the preparation, characterization, and use of lithium phthalocyanine (LiPc) microcrystalline powder as a probe for electron paramagnetic resonance (EPR) oximetry applications has recently been initiated (Ilangovan et al. J. Phys. Chem. B 2000, 104, 4047-4059) Electrochemical preparation of LiPc under potentiostatic conditions (+0.4 V) yielded microcrystalline paramagnetic particles that showed extremely narrow (2 for more than two weeks. Simultaneous measurements of oxygen consumption and oxygen radical generation from X/XO and activated PMNs systems were performed using a combination of the LiPc oximetry probe and DEPMPO spin-trap. The results demonstrated that the LiPc microcrystalline powder could provide accurate and repetitive measurements of oxygen in the medium of its dispersion or in any tissue region of pathophysiological interest.

Original languageEnglish (US)
Pages (from-to)5323-5330
Number of pages8
JournalJournal of Physical Chemistry B
Volume105
Issue number22
DOIs
StatePublished - Jun 7 2001

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ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

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