Electrocardiographic changes with the onset of diabetes and the impact of aerobic exercise training in the Zucker Diabetic Fatty (ZDF) rat

Lisa VanHoose, Youssef Sawers, Rajprasad Loganathan, James L. Vacek, Lisa Stehno-Bittel, Lesya Novikova, Muhammed Al-Jarrah, Irina V. Smirnova

Research output: Contribution to journalArticle

Abstract

Background: Early markers of diabetic autonomic neuropathy (DAN) in an electrocardiogram (ECG) include elevated R wave amplitudes, widening of QT c intervals and decreased heart rate variability (HRV). The severity of DAN has a direct relationship with mortality risk. Aerobic exercise training is a common recommendation for the delay and possible reversal of cardiac dysfunction. Limited research exists on ECG measures for the evaluation of aerobic exercise training in Zucker Diabetic Fatty (ZDF) rat, a model of type 2 diabetes. The objective of this study was to assess whether aerobic exercise training may attenuate diabetes induced ECG changes.Methods: Male ZDF (obese fa/fa) and control Zucker (lean fa/+) rats were assigned to 4 groups: sedentary control (SC), sedentary diabetic (SD), exercised control (EC) and exercised diabetic (ED). The exercised groups began 7 weeks of treadmill training after the development of diabetes in the ED group. Baseline (prior to the training) and termination measurements included body weight, heart weight, blood glucose and glycated hemoglobin levels and ECG parameters. One way repeated measures ANOVA (group) analyzed within and between subject differences and interactions. Pearson coefficients and descriptive statistics described variable relationships and animal characteristics.Results: Diabetes caused crucial changes in R wave amplitudes (p < 0.001), heart rate variability (p < 0.01), QT intervals (p < 0.001) and QT c intervals (p < 0.001). R wave amplitude augmentation in SD rats from baseline to termination was ameliorated by exercise, resulting in R wave amplitude changes in ED animals similar to control rats. Aerobic exercise training neither attenuated QT or QT c interval prolongation nor restored decreases in HRV in diabetic rats.Conclusion: This study revealed alterations in R wave amplitudes, HRV, QT and QT c intervals in ZDF rats. Of these changes, aerobic exercise training was able to correct R wave amplitude changes. In addition, exercise has beneficial effect in this diabetic rat model in regards to ECG correlates of left ventricular mass.

Original languageEnglish (US)
Article number56
JournalCardiovascular Diabetology
Volume9
DOIs
StatePublished - Sep 22 2010
Externally publishedYes

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Exercise
Electrocardiography
Heart Rate
Diabetic Neuropathies
Glycosylated Hemoglobin A
Type 2 Diabetes Mellitus
Blood Glucose
Analysis of Variance
Body Weight
Weights and Measures
Control Groups
Mortality
Research

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Electrocardiographic changes with the onset of diabetes and the impact of aerobic exercise training in the Zucker Diabetic Fatty (ZDF) rat. / VanHoose, Lisa; Sawers, Youssef; Loganathan, Rajprasad; Vacek, James L.; Stehno-Bittel, Lisa; Novikova, Lesya; Al-Jarrah, Muhammed; Smirnova, Irina V.

In: Cardiovascular Diabetology, Vol. 9, 56, 22.09.2010.

Research output: Contribution to journalArticle

VanHoose, Lisa ; Sawers, Youssef ; Loganathan, Rajprasad ; Vacek, James L. ; Stehno-Bittel, Lisa ; Novikova, Lesya ; Al-Jarrah, Muhammed ; Smirnova, Irina V. / Electrocardiographic changes with the onset of diabetes and the impact of aerobic exercise training in the Zucker Diabetic Fatty (ZDF) rat. In: Cardiovascular Diabetology. 2010 ; Vol. 9.
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AU - VanHoose, Lisa

AU - Sawers, Youssef

AU - Loganathan, Rajprasad

AU - Vacek, James L.

AU - Stehno-Bittel, Lisa

AU - Novikova, Lesya

AU - Al-Jarrah, Muhammed

AU - Smirnova, Irina V.

PY - 2010/9/22

Y1 - 2010/9/22

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AB - Background: Early markers of diabetic autonomic neuropathy (DAN) in an electrocardiogram (ECG) include elevated R wave amplitudes, widening of QT c intervals and decreased heart rate variability (HRV). The severity of DAN has a direct relationship with mortality risk. Aerobic exercise training is a common recommendation for the delay and possible reversal of cardiac dysfunction. Limited research exists on ECG measures for the evaluation of aerobic exercise training in Zucker Diabetic Fatty (ZDF) rat, a model of type 2 diabetes. The objective of this study was to assess whether aerobic exercise training may attenuate diabetes induced ECG changes.Methods: Male ZDF (obese fa/fa) and control Zucker (lean fa/+) rats were assigned to 4 groups: sedentary control (SC), sedentary diabetic (SD), exercised control (EC) and exercised diabetic (ED). The exercised groups began 7 weeks of treadmill training after the development of diabetes in the ED group. Baseline (prior to the training) and termination measurements included body weight, heart weight, blood glucose and glycated hemoglobin levels and ECG parameters. One way repeated measures ANOVA (group) analyzed within and between subject differences and interactions. Pearson coefficients and descriptive statistics described variable relationships and animal characteristics.Results: Diabetes caused crucial changes in R wave amplitudes (p < 0.001), heart rate variability (p < 0.01), QT intervals (p < 0.001) and QT c intervals (p < 0.001). R wave amplitude augmentation in SD rats from baseline to termination was ameliorated by exercise, resulting in R wave amplitude changes in ED animals similar to control rats. Aerobic exercise training neither attenuated QT or QT c interval prolongation nor restored decreases in HRV in diabetic rats.Conclusion: This study revealed alterations in R wave amplitudes, HRV, QT and QT c intervals in ZDF rats. Of these changes, aerobic exercise training was able to correct R wave amplitude changes. In addition, exercise has beneficial effect in this diabetic rat model in regards to ECG correlates of left ventricular mass.

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