Electrocardiographic and clinical predictors separating atherosclerotic sudden cardiac death from incident coronary heart disease

Elsayed Z. Soliman, Ronald J. Prineas, L. Douglas Case, Gregory Russell, Wayne Rosamond, Thomas Rea, Nona Sotoodehnia, Wendy S Post, David Siscovick, Bruce M. Psaty, Gregory L. Burke

Research output: Contribution to journalArticle

Abstract

Objective: To identify specific ECG and clinical predictors that separate atherosclerotic sudden cardiac death (SCD) from incident coronary heart disease (CHD) (non-fatal events and non-sudden death) in the combined cohorts of the Atherosclerosis Risk in Communities study and the Cardiovascular Health Study. Methods: This analysis included 18 497 participants (58% females, 24% black individuals, mean age 58 years) who were initially free of clinical CHD. A competing risk analysis was conducted to examine the prognostic significance of baseline clinical characteristics and an extensive electronic database of ECG measurements for prediction of 229 cases of SCD as a first event versus 2297 incident CHD cases (2122 non-fatal events and 175 non-sudden death) that occurred during a median follow-up time of 13 years in the Cardiovascular Health Study and 14 years in the Atherosclerosis Risk in Communities study. Results: After adjusting for common CHD risk factors, a number of clinical characteristics and ECG measurements were independently predictive of SCD and CHD. However, the risk of SCD versus incident CHD was significantly different for race/ethnicity, hypertension, body mass index (BMI), heart rate, QTc, abnormally inverted T wave in any ECG lead group and level of ST elevation in V2. Black race/ethnicity (compared to non-black) was predictive of high SCD risk but less risk of incident CHD (p value for differences in the risk (HR) for SCD versus CHD

Original languageEnglish (US)
Pages (from-to)1597-1601
Number of pages5
JournalHeart
Volume97
Issue number19
DOIs
StatePublished - Oct 2011

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Sudden Cardiac Death
Coronary Disease
Electrocardiography
Atherosclerosis
Health
Body Mass Index
Heart Rate
Databases
Hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Soliman, E. Z., Prineas, R. J., Case, L. D., Russell, G., Rosamond, W., Rea, T., ... Burke, G. L. (2011). Electrocardiographic and clinical predictors separating atherosclerotic sudden cardiac death from incident coronary heart disease. Heart, 97(19), 1597-1601. https://doi.org/10.1136/hrt.2010.215871

Electrocardiographic and clinical predictors separating atherosclerotic sudden cardiac death from incident coronary heart disease. / Soliman, Elsayed Z.; Prineas, Ronald J.; Case, L. Douglas; Russell, Gregory; Rosamond, Wayne; Rea, Thomas; Sotoodehnia, Nona; Post, Wendy S; Siscovick, David; Psaty, Bruce M.; Burke, Gregory L.

In: Heart, Vol. 97, No. 19, 10.2011, p. 1597-1601.

Research output: Contribution to journalArticle

Soliman, EZ, Prineas, RJ, Case, LD, Russell, G, Rosamond, W, Rea, T, Sotoodehnia, N, Post, WS, Siscovick, D, Psaty, BM & Burke, GL 2011, 'Electrocardiographic and clinical predictors separating atherosclerotic sudden cardiac death from incident coronary heart disease', Heart, vol. 97, no. 19, pp. 1597-1601. https://doi.org/10.1136/hrt.2010.215871
Soliman, Elsayed Z. ; Prineas, Ronald J. ; Case, L. Douglas ; Russell, Gregory ; Rosamond, Wayne ; Rea, Thomas ; Sotoodehnia, Nona ; Post, Wendy S ; Siscovick, David ; Psaty, Bruce M. ; Burke, Gregory L. / Electrocardiographic and clinical predictors separating atherosclerotic sudden cardiac death from incident coronary heart disease. In: Heart. 2011 ; Vol. 97, No. 19. pp. 1597-1601.
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