Electrical stimulation of the lingual musculature in obstructive sleep apnea

Alan R Schwartz, David W Eisele, Anil Hari, Roy Testerman, Donald Erickson, Philip L Smith

Research output: Contribution to journalArticle

Abstract

The influence of lingual muscle activity on airflow dynamics in the upper airway was examined in nine patients with obstructive sleep apnea. Muscles that retract the tongue (hyoglossus and styloglossus) and protrude the tongue (genioglossus) were selectively stimulated electrically during sleep with fine wire electrodes placed intramuscularly transorally. We confirmed that stimulation with 50 Hz and 40-μs pulse duration did not elicit changes in electroencephalographic patterns or heart rate or alter airflow after the stimulation burst had ceased. The highest stimulus intensity that did not arouse patients from sleep was then utilized to examine the effect of lingual muscle recruitment on airflow dynamics during steady-state periods of inspiratory airflow limitation. When applying a stimulus burst during single inspirations, maximal inspiratory airflow decreased by 239 ± 177 ml/s (P <0.05) during retractor stimulation, whereas maximal inspiratory airflow increased by 217 ± 93 ml/s during protrusor stimulation (P <0.001) compared with breaths immediately before and after the stimulated breath. When consecutive inspirations were stimulated repeatedly, protrusor stimulation decreased the frequency of obstructive breathing episodes in four patients breathing at 3.9 ± 3.4 (SD) cmH2O nasal pressure. The findings suggest that stimulation of the lingual muscles can increase or decrease airflow depending on the specific muscles stimulated without arousing patients from sleep.

Original languageEnglish (US)
Pages (from-to)643-652
Number of pages10
JournalJournal of Applied Physiology
Volume81
Issue number2
StatePublished - Aug 1996

Fingerprint

Obstructive Sleep Apnea
Tongue
Electric Stimulation
Muscles
Sleep
Respiration
Nose
Electrodes
Heart Rate
Pressure

Keywords

  • electrical stimulation
  • genioglossus
  • hypoglossus
  • pharynx
  • styloglossus
  • upper airway

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Electrical stimulation of the lingual musculature in obstructive sleep apnea. / Schwartz, Alan R; Eisele, David W; Hari, Anil; Testerman, Roy; Erickson, Donald; Smith, Philip L.

In: Journal of Applied Physiology, Vol. 81, No. 2, 08.1996, p. 643-652.

Research output: Contribution to journalArticle

Schwartz, AR, Eisele, DW, Hari, A, Testerman, R, Erickson, D & Smith, PL 1996, 'Electrical stimulation of the lingual musculature in obstructive sleep apnea', Journal of Applied Physiology, vol. 81, no. 2, pp. 643-652.
Schwartz, Alan R ; Eisele, David W ; Hari, Anil ; Testerman, Roy ; Erickson, Donald ; Smith, Philip L. / Electrical stimulation of the lingual musculature in obstructive sleep apnea. In: Journal of Applied Physiology. 1996 ; Vol. 81, No. 2. pp. 643-652.
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