Electrical stimulation and testosterone enhance recovery from recurrent laryngeal nerve crush

Gina N. Monaco, Todd J. Brown, Ryan C. Burgette, Keith N. Fargo, Lee M Akst, Kathryn J. Jones, Eileen M. Foecking

Research output: Contribution to journalArticle

Abstract

Objective: This study investigated the effects of a combinatorial treatment, consisting of a brief period of nerve electrical stimulation (ES) and systemic supraphysiologic testosterone, on functional recovery following a crush of the recurrent laryngeal nerve (RLN). Study design: Prospective, controlled animal study. Methods: After a crush of the left RLN, adult male Sprague-Dawley rats were divided into four treatment groups: 1) no treatment, 2) ES, 3) testosterone propionate (TP), and 4) ES + TP. Each group was subdivided into 1, 2, 3, or 4 weeks post-operative survival time points. Groups had an n of 4-9. Recovery of vocal fold mobility (VFM) was assessed. Results: Brief ES of the proximal nerve alone or in combination with TP accelerated the initiation of functional recovery. TP administration by itself also produced increased VFM scores compared to controls, but there were no statistical differences between the ES-treated and TP-treated animals. Treatment with brief ES alone was sufficient to decrease the time required to recover complete VFM. Animals with complete VFM were seen in treatment groups as early as 1 week following injury; in the untreated group, this was not observed until at least 3 weeks post-injury, translating into a 66% decrease in time to complete recovery. Conclusions: Brief ES, alone or in combination with TP, promise to be effective therapeutic interventions for promoting regeneration following RLN injury.

Original languageEnglish (US)
Pages (from-to)571-578
Number of pages8
JournalRestorative Neurology and Neuroscience
Volume33
Issue number4
DOIs
StatePublished - Aug 19 2015
Externally publishedYes

Fingerprint

Nerve Crush
Recurrent Laryngeal Nerve
Testosterone Propionate
Electric Stimulation
Testosterone
Vocal Cords
Therapeutics
Recurrent Laryngeal Nerve Injuries
Wounds and Injuries
Operative Time
Sprague Dawley Rats
Regeneration
Prospective Studies

Keywords

  • androgen
  • Axotomy
  • electrical stimulation
  • functional recovery
  • rat
  • recurrent laryngeal nerve
  • regeneration
  • vocal fold

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Monaco, G. N., Brown, T. J., Burgette, R. C., Fargo, K. N., Akst, L. M., Jones, K. J., & Foecking, E. M. (2015). Electrical stimulation and testosterone enhance recovery from recurrent laryngeal nerve crush. Restorative Neurology and Neuroscience, 33(4), 571-578. https://doi.org/10.3233/RNN-130334

Electrical stimulation and testosterone enhance recovery from recurrent laryngeal nerve crush. / Monaco, Gina N.; Brown, Todd J.; Burgette, Ryan C.; Fargo, Keith N.; Akst, Lee M; Jones, Kathryn J.; Foecking, Eileen M.

In: Restorative Neurology and Neuroscience, Vol. 33, No. 4, 19.08.2015, p. 571-578.

Research output: Contribution to journalArticle

Monaco, Gina N. ; Brown, Todd J. ; Burgette, Ryan C. ; Fargo, Keith N. ; Akst, Lee M ; Jones, Kathryn J. ; Foecking, Eileen M. / Electrical stimulation and testosterone enhance recovery from recurrent laryngeal nerve crush. In: Restorative Neurology and Neuroscience. 2015 ; Vol. 33, No. 4. pp. 571-578.
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