Electrical impedance myography in duchenne muscular dystrophy and healthy controls: A multicenter study of reliability and validity

and the DART-EIM Clinical Evaluators Consortium

Research output: Contribution to journalArticle

Abstract

Introduction: Electrical impedance myography (EIM) is a non-invasive, painless, objective technique to quantify muscle pathology. Methods: We measured EIM in 8 arm and leg muscles in 61 boys with Duchenne muscular dystrophy (DMD) and 31 healthy boys, ages 3-12 years, at 5 centers. We determined the reliability of EIM and compared results in boys with DMD to controls and to 6-minute walk distance (6MWD), North Star Ambulatory Assessment (NSAA), timed functional tests (TFTs), and strength (hand-held dynamometry). Results: EIM was well tolerated and had good inter- and intrarater reliability (intraclass correlation coefficient 0.81-0.96). The averaged EIM phase value from all muscles was higher (P<0.001) in controls (10.45±2.29) than boys with DMD (7.31±2.23), and correlated (P≤0.001) with 6MWD (r=0.55), NSAA (r=0.66), TFTs (r=-0.56), and strength (r=0.44). Conclusion: EIM is a reliable and valid measure of disease severity in DMD. Longitudinal studies comparing EIM with other assessments over time in DMD are warranted.

Original languageEnglish (US)
Pages (from-to)592-597
Number of pages6
JournalMuscle and Nerve
Volume52
Issue number4
DOIs
StatePublished - Oct 1 2015

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Keywords

  • Biomarker
  • Children
  • Duchenne muscular dystrophy
  • Electrical impedance myography
  • Myopathy

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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