Electrical impedance myography correlates with standard measures of ALS severity

Seward B. Rutkove; James B. Caress; Michael S. Cartwright; Ted M. Burns; Judy Warder; William S. David; Namita Goyal; Nicholas J. Maragakis; Michael Benatar; Khema R. Sharma; Pushpa Narayanaswami; Elizabeth M. Raynor; Mary Lou Watson; Jeremy M. Shefner

doi:10.1002/mus.24128

Electrical impedance myography correlates with standard measures of ALS severity

Seward B. Rutkove, James B. Caress, Michael S. Cartwright, Ted M. Burns, Judy Warder, William S. David, Namita Goyal, Nicholas J. Maragakis, Michael Benatar, Khema R. Sharma, Pushpa Narayanaswami, Elizabeth M. Raynor, Mary Lou Watson, Jeremy M. Shefner

School of Medicine

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Introduction: Electrical impedance myography (EIM) can be used to assess amyotrophic lateral sclerosis (ALS) progression. The relationship between EIM values and standard assessment measures, however, is unknown. Methods: EIM 50 kHz phase data from 60 subjects who participated in a longitudinal natural history study of ALS were correlated with handheld dynamometry (HHD), the ALS Functional Rating Scale-Revised (ALSFRS-R) score, and motor unit number estimation (MUNE). Results: Moderate strength correlations between EIM parameters and HHD were observed for both whole-body and individual upper and lower extremity values. Similarly, moderate strength correlations were observed between EIM and ALSFRS-R upper and lower extremity subscores, but not total ALSFRS-R scores. MUNE correlated significantly with single muscle EIM data but not with whole body or upper or lower extremity values. Conclusions: These results support the concept that EIM can serve as a meaningful measure of disease severity in ALS.

Original language	English (US)
Pages (from-to)	441-443
Number of pages	3
Journal	Muscle and Nerve
Volume	49
Issue number	3
DOIs	https://doi.org/10.1002/mus.24128
State	Published - Mar 2014

Keywords

ALSFRS-R
Amyotrophic lateral sclerosis
Biomarkers
Electrical impedance myography
Handheld dynamometry

ASJC Scopus subject areas

Physiology
Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)

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Rutkove, S. B., Caress, J. B., Cartwright, M. S., Burns, T. M., Warder, J., David, W. S., Goyal, N., Maragakis, N. J., Benatar, M., Sharma, K. R., Narayanaswami, P., Raynor, E. M., Watson, M. L., & Shefner, J. M. (2014). Electrical impedance myography correlates with standard measures of ALS severity. Muscle and Nerve, 49(3), 441-443. https://doi.org/10.1002/mus.24128

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title = "Electrical impedance myography correlates with standard measures of ALS severity",

abstract = "Introduction: Electrical impedance myography (EIM) can be used to assess amyotrophic lateral sclerosis (ALS) progression. The relationship between EIM values and standard assessment measures, however, is unknown. Methods: EIM 50 kHz phase data from 60 subjects who participated in a longitudinal natural history study of ALS were correlated with handheld dynamometry (HHD), the ALS Functional Rating Scale-Revised (ALSFRS-R) score, and motor unit number estimation (MUNE). Results: Moderate strength correlations between EIM parameters and HHD were observed for both whole-body and individual upper and lower extremity values. Similarly, moderate strength correlations were observed between EIM and ALSFRS-R upper and lower extremity subscores, but not total ALSFRS-R scores. MUNE correlated significantly with single muscle EIM data but not with whole body or upper or lower extremity values. Conclusions: These results support the concept that EIM can serve as a meaningful measure of disease severity in ALS.",

keywords = "ALSFRS-R, Amyotrophic lateral sclerosis, Biomarkers, Electrical impedance myography, Handheld dynamometry",

author = "Rutkove, {Seward B.} and Caress, {James B.} and Cartwright, {Michael S.} and Burns, {Ted M.} and Judy Warder and David, {William S.} and Namita Goyal and Maragakis, {Nicholas J.} and Michael Benatar and Sharma, {Khema R.} and Pushpa Narayanaswami and Raynor, {Elizabeth M.} and Watson, {Mary Lou} and Shefner, {Jeremy M.}",

year = "2014",

month = mar,

doi = "10.1002/mus.24128",

language = "English (US)",

volume = "49",

pages = "441--443",

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AU - Caress, James B.

AU - Cartwright, Michael S.

AU - Burns, Ted M.

AU - Warder, Judy

AU - David, William S.

AU - Goyal, Namita

AU - Maragakis, Nicholas J.

AU - Benatar, Michael

AU - Sharma, Khema R.

AU - Narayanaswami, Pushpa

AU - Raynor, Elizabeth M.

AU - Watson, Mary Lou

AU - Shefner, Jeremy M.

PY - 2014/3

Y1 - 2014/3

N2 - Introduction: Electrical impedance myography (EIM) can be used to assess amyotrophic lateral sclerosis (ALS) progression. The relationship between EIM values and standard assessment measures, however, is unknown. Methods: EIM 50 kHz phase data from 60 subjects who participated in a longitudinal natural history study of ALS were correlated with handheld dynamometry (HHD), the ALS Functional Rating Scale-Revised (ALSFRS-R) score, and motor unit number estimation (MUNE). Results: Moderate strength correlations between EIM parameters and HHD were observed for both whole-body and individual upper and lower extremity values. Similarly, moderate strength correlations were observed between EIM and ALSFRS-R upper and lower extremity subscores, but not total ALSFRS-R scores. MUNE correlated significantly with single muscle EIM data but not with whole body or upper or lower extremity values. Conclusions: These results support the concept that EIM can serve as a meaningful measure of disease severity in ALS.

AB - Introduction: Electrical impedance myography (EIM) can be used to assess amyotrophic lateral sclerosis (ALS) progression. The relationship between EIM values and standard assessment measures, however, is unknown. Methods: EIM 50 kHz phase data from 60 subjects who participated in a longitudinal natural history study of ALS were correlated with handheld dynamometry (HHD), the ALS Functional Rating Scale-Revised (ALSFRS-R) score, and motor unit number estimation (MUNE). Results: Moderate strength correlations between EIM parameters and HHD were observed for both whole-body and individual upper and lower extremity values. Similarly, moderate strength correlations were observed between EIM and ALSFRS-R upper and lower extremity subscores, but not total ALSFRS-R scores. MUNE correlated significantly with single muscle EIM data but not with whole body or upper or lower extremity values. Conclusions: These results support the concept that EIM can serve as a meaningful measure of disease severity in ALS.

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Electrical impedance myography correlates with standard measures of ALS severity

Abstract

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ASJC Scopus subject areas

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