Electrical brain stimulation in different variants of primary progressive aphasia: A randomized clinical trial

Kyrana Tsapkini; Kimberly T. Webster; Bronte N. Ficek; John E. Desmond; Chiadi U. Onyike; Brenda Rapp; Constantine E. Frangakis; Argye E. Hillis

doi:10.1016/j.trci.2018.08.002

Electrical brain stimulation in different variants of primary progressive aphasia: A randomized clinical trial

Kyrana Tsapkini, Kimberly T. Webster, Bronte N. Ficek, John E. Desmond, Chiadi U. Onyike, Brenda Rapp, Constantine E. Frangakis, Argye E. Hillis

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Introduction: Transcranial direct current stimulation (tDCS) has been recently shown to improve language outcomes in primary progressive aphasia (PPA) but most studies are small and the influence of PPA variant is unknown. Methods: Thirty-six patients with PPA participated in a randomized, sham-controlled, double-blind, within-subject crossover design for 15 daily sessions of stimulation coupled with written naming/spelling therapy. Outcome measures were letter accuracy of treated and untreated words immediately after and at 2 weeks and 2 months posttreatment. Results: tDCS treatment was more effective than sham: gains for treated words were maintained 2 months posttreatment; gains from tDCS also generalized to untreated words and were sustained 2 months posttreatment. Different effects were obtained for each PPA variant, with no tDCS advantage for semantic variant PPA. Discussion: The study supports using tDCS as an adjunct to written language interventions in individuals with logopenic or nonfluent/agrammatic PPA seeking compensatory treatments in clinical settings.

Original language	English (US)
Pages (from-to)	461-472
Number of pages	12
Journal	Alzheimer's and Dementia: Translational Research and Clinical Interventions
Volume	4
DOIs	https://doi.org/10.1016/j.trci.2018.08.002
State	Published - Jan 1 2018

Keywords

Alzheimer's disease
Dementia
Frontotemporal dementia
Language
Naming
Primary progressive aphasia
Spelling
Treatment
lvPPA
nfvPPA
svPPA

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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10.1016/j.trci.2018.08.002

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Tsapkini, K., Webster, K. T., Ficek, B. N., Desmond, J. E., Onyike, C. U., Rapp, B., Frangakis, C. E., & Hillis, A. E. (2018). Electrical brain stimulation in different variants of primary progressive aphasia: A randomized clinical trial. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 4, 461-472. https://doi.org/10.1016/j.trci.2018.08.002

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title = "Electrical brain stimulation in different variants of primary progressive aphasia: A randomized clinical trial",

abstract = "Introduction: Transcranial direct current stimulation (tDCS) has been recently shown to improve language outcomes in primary progressive aphasia (PPA) but most studies are small and the influence of PPA variant is unknown. Methods: Thirty-six patients with PPA participated in a randomized, sham-controlled, double-blind, within-subject crossover design for 15 daily sessions of stimulation coupled with written naming/spelling therapy. Outcome measures were letter accuracy of treated and untreated words immediately after and at 2 weeks and 2 months posttreatment. Results: tDCS treatment was more effective than sham: gains for treated words were maintained 2 months posttreatment; gains from tDCS also generalized to untreated words and were sustained 2 months posttreatment. Different effects were obtained for each PPA variant, with no tDCS advantage for semantic variant PPA. Discussion: The study supports using tDCS as an adjunct to written language interventions in individuals with logopenic or nonfluent/agrammatic PPA seeking compensatory treatments in clinical settings.",

keywords = "Alzheimer's disease, Dementia, Frontotemporal dementia, Language, Naming, Primary progressive aphasia, Spelling, Treatment, lvPPA, nfvPPA, svPPA",

author = "Kyrana Tsapkini and Webster, {Kimberly T.} and Ficek, {Bronte N.} and Desmond, {John E.} and Onyike, {Chiadi U.} and Brenda Rapp and Frangakis, {Constantine E.} and Hillis, {Argye E.}",

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doi = "10.1016/j.trci.2018.08.002",

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AU - Rapp, Brenda

AU - Frangakis, Constantine E.

AU - Hillis, Argye E.

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KW - nfvPPA

KW - svPPA

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Electrical brain stimulation in different variants of primary progressive aphasia: A randomized clinical trial

Abstract

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