Electrical brain stimulation in different variants of primary progressive aphasia

A randomized clinical trial

Research output: Contribution to journalArticle

Abstract

Introduction: Transcranial direct current stimulation (tDCS) has been recently shown to improve language outcomes in primary progressive aphasia (PPA) but most studies are small and the influence of PPA variant is unknown. Methods: Thirty-six patients with PPA participated in a randomized, sham-controlled, double-blind, within-subject crossover design for 15 daily sessions of stimulation coupled with written naming/spelling therapy. Outcome measures were letter accuracy of treated and untreated words immediately after and at 2 weeks and 2 months posttreatment. Results: tDCS treatment was more effective than sham: gains for treated words were maintained 2 months posttreatment; gains from tDCS also generalized to untreated words and were sustained 2 months posttreatment. Different effects were obtained for each PPA variant, with no tDCS advantage for semantic variant PPA. Discussion: The study supports using tDCS as an adjunct to written language interventions in individuals with logopenic or nonfluent/agrammatic PPA seeking compensatory treatments in clinical settings.

Original languageEnglish (US)
Pages (from-to)461-472
Number of pages12
JournalAlzheimer's and Dementia: Translational Research and Clinical Interventions
Volume4
DOIs
StatePublished - Jan 1 2018

Fingerprint

Primary Progressive Aphasia
Deep Brain Stimulation
Randomized Controlled Trials
Primary Progressive Nonfluent Aphasia
Language
Semantics
Cross-Over Studies
Therapeutics
Outcome Assessment (Health Care)
Transcranial Direct Current Stimulation

Keywords

  • Alzheimer's disease
  • Dementia
  • Frontotemporal dementia
  • Language
  • lvPPA
  • Naming
  • nfvPPA
  • Primary progressive aphasia
  • Spelling
  • svPPA
  • Treatment

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

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title = "Electrical brain stimulation in different variants of primary progressive aphasia: A randomized clinical trial",
abstract = "Introduction: Transcranial direct current stimulation (tDCS) has been recently shown to improve language outcomes in primary progressive aphasia (PPA) but most studies are small and the influence of PPA variant is unknown. Methods: Thirty-six patients with PPA participated in a randomized, sham-controlled, double-blind, within-subject crossover design for 15 daily sessions of stimulation coupled with written naming/spelling therapy. Outcome measures were letter accuracy of treated and untreated words immediately after and at 2 weeks and 2 months posttreatment. Results: tDCS treatment was more effective than sham: gains for treated words were maintained 2 months posttreatment; gains from tDCS also generalized to untreated words and were sustained 2 months posttreatment. Different effects were obtained for each PPA variant, with no tDCS advantage for semantic variant PPA. Discussion: The study supports using tDCS as an adjunct to written language interventions in individuals with logopenic or nonfluent/agrammatic PPA seeking compensatory treatments in clinical settings.",
keywords = "Alzheimer's disease, Dementia, Frontotemporal dementia, Language, lvPPA, Naming, nfvPPA, Primary progressive aphasia, Spelling, svPPA, Treatment",
author = "Kyrana Tsapkini and Webster, {Kimberly T} and Ficek, {Bronte N.} and John Desmond and Onyike, {Chiadikaobi U} and Rapp, {Brenda C} and Constantine Frangakis and Argye Hillis-Trupe",
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doi = "10.1016/j.trci.2018.08.002",
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T2 - A randomized clinical trial

AU - Tsapkini, Kyrana

AU - Webster, Kimberly T

AU - Ficek, Bronte N.

AU - Desmond, John

AU - Onyike, Chiadikaobi U

AU - Rapp, Brenda C

AU - Frangakis, Constantine

AU - Hillis-Trupe, Argye

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AB - Introduction: Transcranial direct current stimulation (tDCS) has been recently shown to improve language outcomes in primary progressive aphasia (PPA) but most studies are small and the influence of PPA variant is unknown. Methods: Thirty-six patients with PPA participated in a randomized, sham-controlled, double-blind, within-subject crossover design for 15 daily sessions of stimulation coupled with written naming/spelling therapy. Outcome measures were letter accuracy of treated and untreated words immediately after and at 2 weeks and 2 months posttreatment. Results: tDCS treatment was more effective than sham: gains for treated words were maintained 2 months posttreatment; gains from tDCS also generalized to untreated words and were sustained 2 months posttreatment. Different effects were obtained for each PPA variant, with no tDCS advantage for semantic variant PPA. Discussion: The study supports using tDCS as an adjunct to written language interventions in individuals with logopenic or nonfluent/agrammatic PPA seeking compensatory treatments in clinical settings.

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