Elaboration of human chorionic gonadotropin by lung tumors. An immunocytochemical study

T. S. Wilson, E. M. McDowell, K. R. McIntire, B. F. Trump

Research output: Contribution to journalArticlepeer-review

Abstract

The highly sensitive peroxidase-antiperoxidase immunocytochemical method was used to demonstrate the presence of the β-subunit of human chorionic gonadotropin (HCG) within paraffin sections of human lung tumors of diverse histologic patterns. Of the 61 tumors studied, 51 (84%) displayed HCG-like immunoreactivity. This is a much higher incidence than was expected considering studies by other investigators in which serum samples from patients with lung cancer were assayed for HCG. Our results are, however, consistent with data from studies by other investigators in which tumor extracts were assayed for HCG. In addition, it was found that HCG production was often linked with glycogen storage within tumor cells. This may explain the association of HCG production with large-cell carcinomas of the lung, because these tumors often contain copious quantities of glycogen.

Original languageEnglish (US)
Pages (from-to)169-173
Number of pages5
JournalArchives of Pathology and Laboratory Medicine
Volume105
Issue number4
StatePublished - Jan 1 1981
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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