Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2

Arthur Burnett, Devin G. Johns, Lance J. Kriegsfeld, Sabra L Klein, David C. Calbin, Gregory E. Demas, Lawrence Schramm, Susumu Tonegawa, Randy J. Nelson, Solomon H Snyder, Kenneth D. Poss

Research output: Contribution to journalArticle

Abstract

Nitric oxide (NO) is well established as a neurotransmitter in the central and peripheral nervous systems. More recently, another gas, carbon monoxide (CO) has also been implicated in neurotransmission. In the nervous system CO is formed by a subtype of heme oxygenase (HO) designated HO2 (ref. 2). HO2 is localized to discrete neuronal populations in the brain resembling localizations of soluble guanylyl cyclase, which is activated by CO (ref. 3). CO may also function in the peripheral autonomic nervous system, in conjunction with NO. The majority of ganglia in the myenteric plexus possess both HO2 and neuronal NO synthase (NOS)4. Defects in myenteric plexus neurotransmission occur both in mice with targeted deletion of genes for HO2 and neuronal NOS (ref. 5). HO2 also occurs in other autonomic ganglia including the petrosal, superior cervical and nodose ganglia. Neuronal NOS is localized to neurons regulating male reproductive behavior, such as penile erection, and NOS inhibitors prevent erection. Because of the other parallels between NO and CO, we speculated that CO may play a role in male reproductive behavior. In the present study we describe HO2 localization in neuronal structures regulating copulatory reflexes. Reflex activity of the bulbospongiosus muscle, which mediates ejaculation and ejaculatory behavior, is markedly diminished in mice with targeted deletion of the gene for HO2 (HO2-).

Original languageEnglish (US)
Pages (from-to)84-87
Number of pages4
JournalNature Medicine
Volume4
Issue number1
DOIs
StatePublished - 1998

Fingerprint

Carbon Monoxide
Genes
Neurology
Nitric Oxide Synthase
Reproductive Behavior
Myenteric Plexus
Nitric Oxide
Gene Deletion
Peripheral Nervous System
Synaptic Transmission
Reflex
Autonomic Ganglia
Nodose Ganglion
Penile Erection
Heme Oxygenase (Decyclizing)
Superior Cervical Ganglion
Nitric Oxide Synthase Type I
Ejaculation
Guanylate Cyclase
Autonomic Nervous System

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2. / Burnett, Arthur; Johns, Devin G.; Kriegsfeld, Lance J.; Klein, Sabra L; Calbin, David C.; Demas, Gregory E.; Schramm, Lawrence; Tonegawa, Susumu; Nelson, Randy J.; Snyder, Solomon H; Poss, Kenneth D.

In: Nature Medicine, Vol. 4, No. 1, 1998, p. 84-87.

Research output: Contribution to journalArticle

Burnett, A, Johns, DG, Kriegsfeld, LJ, Klein, SL, Calbin, DC, Demas, GE, Schramm, L, Tonegawa, S, Nelson, RJ, Snyder, SH & Poss, KD 1998, 'Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2', Nature Medicine, vol. 4, no. 1, pp. 84-87. https://doi.org/10.1038/nm0198-084
Burnett, Arthur ; Johns, Devin G. ; Kriegsfeld, Lance J. ; Klein, Sabra L ; Calbin, David C. ; Demas, Gregory E. ; Schramm, Lawrence ; Tonegawa, Susumu ; Nelson, Randy J. ; Snyder, Solomon H ; Poss, Kenneth D. / Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2. In: Nature Medicine. 1998 ; Vol. 4, No. 1. pp. 84-87.
@article{7eab4036e84249eebc2a9e09d5169443,
title = "Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2",
abstract = "Nitric oxide (NO) is well established as a neurotransmitter in the central and peripheral nervous systems. More recently, another gas, carbon monoxide (CO) has also been implicated in neurotransmission. In the nervous system CO is formed by a subtype of heme oxygenase (HO) designated HO2 (ref. 2). HO2 is localized to discrete neuronal populations in the brain resembling localizations of soluble guanylyl cyclase, which is activated by CO (ref. 3). CO may also function in the peripheral autonomic nervous system, in conjunction with NO. The majority of ganglia in the myenteric plexus possess both HO2 and neuronal NO synthase (NOS)4. Defects in myenteric plexus neurotransmission occur both in mice with targeted deletion of genes for HO2 and neuronal NOS (ref. 5). HO2 also occurs in other autonomic ganglia including the petrosal, superior cervical and nodose ganglia. Neuronal NOS is localized to neurons regulating male reproductive behavior, such as penile erection, and NOS inhibitors prevent erection. Because of the other parallels between NO and CO, we speculated that CO may play a role in male reproductive behavior. In the present study we describe HO2 localization in neuronal structures regulating copulatory reflexes. Reflex activity of the bulbospongiosus muscle, which mediates ejaculation and ejaculatory behavior, is markedly diminished in mice with targeted deletion of the gene for HO2 (HO2-).",
author = "Arthur Burnett and Johns, {Devin G.} and Kriegsfeld, {Lance J.} and Klein, {Sabra L} and Calbin, {David C.} and Demas, {Gregory E.} and Lawrence Schramm and Susumu Tonegawa and Nelson, {Randy J.} and Snyder, {Solomon H} and Poss, {Kenneth D.}",
year = "1998",
doi = "10.1038/nm0198-084",
language = "English (US)",
volume = "4",
pages = "84--87",
journal = "Nature Medicine",
issn = "1078-8956",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2

AU - Burnett, Arthur

AU - Johns, Devin G.

AU - Kriegsfeld, Lance J.

AU - Klein, Sabra L

AU - Calbin, David C.

AU - Demas, Gregory E.

AU - Schramm, Lawrence

AU - Tonegawa, Susumu

AU - Nelson, Randy J.

AU - Snyder, Solomon H

AU - Poss, Kenneth D.

PY - 1998

Y1 - 1998

N2 - Nitric oxide (NO) is well established as a neurotransmitter in the central and peripheral nervous systems. More recently, another gas, carbon monoxide (CO) has also been implicated in neurotransmission. In the nervous system CO is formed by a subtype of heme oxygenase (HO) designated HO2 (ref. 2). HO2 is localized to discrete neuronal populations in the brain resembling localizations of soluble guanylyl cyclase, which is activated by CO (ref. 3). CO may also function in the peripheral autonomic nervous system, in conjunction with NO. The majority of ganglia in the myenteric plexus possess both HO2 and neuronal NO synthase (NOS)4. Defects in myenteric plexus neurotransmission occur both in mice with targeted deletion of genes for HO2 and neuronal NOS (ref. 5). HO2 also occurs in other autonomic ganglia including the petrosal, superior cervical and nodose ganglia. Neuronal NOS is localized to neurons regulating male reproductive behavior, such as penile erection, and NOS inhibitors prevent erection. Because of the other parallels between NO and CO, we speculated that CO may play a role in male reproductive behavior. In the present study we describe HO2 localization in neuronal structures regulating copulatory reflexes. Reflex activity of the bulbospongiosus muscle, which mediates ejaculation and ejaculatory behavior, is markedly diminished in mice with targeted deletion of the gene for HO2 (HO2-).

AB - Nitric oxide (NO) is well established as a neurotransmitter in the central and peripheral nervous systems. More recently, another gas, carbon monoxide (CO) has also been implicated in neurotransmission. In the nervous system CO is formed by a subtype of heme oxygenase (HO) designated HO2 (ref. 2). HO2 is localized to discrete neuronal populations in the brain resembling localizations of soluble guanylyl cyclase, which is activated by CO (ref. 3). CO may also function in the peripheral autonomic nervous system, in conjunction with NO. The majority of ganglia in the myenteric plexus possess both HO2 and neuronal NO synthase (NOS)4. Defects in myenteric plexus neurotransmission occur both in mice with targeted deletion of genes for HO2 and neuronal NOS (ref. 5). HO2 also occurs in other autonomic ganglia including the petrosal, superior cervical and nodose ganglia. Neuronal NOS is localized to neurons regulating male reproductive behavior, such as penile erection, and NOS inhibitors prevent erection. Because of the other parallels between NO and CO, we speculated that CO may play a role in male reproductive behavior. In the present study we describe HO2 localization in neuronal structures regulating copulatory reflexes. Reflex activity of the bulbospongiosus muscle, which mediates ejaculation and ejaculatory behavior, is markedly diminished in mice with targeted deletion of the gene for HO2 (HO2-).

UR - http://www.scopus.com/inward/record.url?scp=0031913770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031913770&partnerID=8YFLogxK

U2 - 10.1038/nm0198-084

DO - 10.1038/nm0198-084

M3 - Article

VL - 4

SP - 84

EP - 87

JO - Nature Medicine

JF - Nature Medicine

SN - 1078-8956

IS - 1

ER -